SPCC777.17c Antibody

IL-17C Antibody Overview

IL-17C is a pro-inflammatory cytokine involved in epithelial innate immunity, signaling through NF-kappa-B and MAPK pathways to induce antibacterial peptides (e.g., S100A8, REG3A) and pro-inflammatory molecules . IL-17C antibodies are used in research to study its role in autoimmune diseases (e.g., atopic dermatitis) and epithelial homeostasis.

Key IL-17C Antibodies from Search Results

The following antibodies were identified in the search results, with specifications and applications:

Clinical Studies on IL-17C Antibodies

• MOR106 (Anti-IL-17C monoclonal antibody): Tested in Phase 1/2 trials for atopic dermatitis (NCT03568071, NCT03689829, NCT03864627). Results showed:

  • Safety: Well-tolerated with bioavailability of 55% (s.c.) and steady-state levels achieved in 2–4 weeks .

  • Efficacy: Futility analysis led to trial termination due to low probability of achieving primary endpoints (e.g., EASI50 response) .

Research Applications of IL-17C Antibodies

• Immunohistochemistry (IHC): Used to detect IL-17C in human Crohn’s intestine (R&D Systems MAB1234) .

• Flow Cytometry: Staining of PC-3 human prostate cancer cells (R&D Systems IC1234A) .

• ELISA: Quantification of IL-17C in cell culture supernatants (Cusabio CSB-PA959846) .