RNF138 Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery timelines may vary depending on the purchase method and location. Please contact your local distributor for specific delivery information.
Synonyms
E3 ubiquitin protein ligase RNF138 antibody; E3 ubiquitin-protein ligase RNF138 antibody; hNARF antibody; HSD 4 antibody; HSD4 antibody; MGC8758 antibody; NARF antibody; Nemo like kinase associated RING finger protein antibody; Nemo-like kinase-associated RING finger protein antibody; NLK associated RING finger protein antibody; NLK-associated RING finger protein antibody; RING finger protein 138 antibody; ring finger protein 138, E3 ubiquitin protein ligase antibody; RN138_HUMAN antibody; Rnf138 antibody; STRIN antibody
Target Names
RNF138
Uniprot No.
Target Background
Function
RNF138 is an E3 ubiquitin-protein ligase that plays a crucial role in the DNA damage response by promoting DNA resection and homologous recombination. It is recruited to sites of double-strand breaks following DNA damage and specifically facilitates double-strand break repair via homologous recombination. Two distinct, non-exclusive mechanisms have been proposed to explain its role:
1. RNF138 is believed to regulate the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ). This is achieved by mediating the ubiquitination of XRCC5/Ku80, leading to the removal of the Ku complex from DNA breaks, thereby promoting homologous recombination.
2. Alternatively, RNF138 collaborates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating the ubiquitination of RBBP8/CtIP.
Furthermore, RNF138, in conjunction with NLK, participates in the ubiquitination and degradation of TCF/LEF. It also exhibits auto-ubiquitination activity in combination with UBE2K. RNF138 may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
1. RNF138 is believed to regulate the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ). This is achieved by mediating the ubiquitination of XRCC5/Ku80, leading to the removal of the Ku complex from DNA breaks, thereby promoting homologous recombination.
2. Alternatively, RNF138 collaborates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating the ubiquitination of RBBP8/CtIP.
Furthermore, RNF138, in conjunction with NLK, participates in the ubiquitination and degradation of TCF/LEF. It also exhibits auto-ubiquitination activity in combination with UBE2K. RNF138 may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Gene References Into Functions
- A study suggested that RNF138 is essential for the proliferation, migration, and invasion of glioma cells. Its downregulation inhibited the epithelial-mesenchymal transition (EMT) process by suppressing the Erk signaling pathway in glioma. PMID: 30272353
- This study identified RNF138 as the E3 ubiquitin ligase responsible for promoting EA2-associated aberrant degradation of the human CaV2.1 protein. PMID: 28167673
- Rad51d mediated by E3 Ligase Rnf138 plays a role in the homologous recombination repair pathway PMID: 27195665
- RNF138 is a newly identified regulatory component of the HR-mediated DNA repair pathway that has implications for understanding how ubiquitination modifies the functions of the RAD51 paralog protein complex PMID: 27161866
- Data demonstrate that ubiquitin E3 ligase RNF138 regulates Ku80 antigen ubiquitylation in response to DNA damage. PMID: 26502055
- Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. PMID: 26502057
- The RNF138 gene is highly expressed in glioma tissue and glioma cell lines and plays a significant role in glioma cell proliferation, apoptosis, and cell cycle. PMID: 22155992
Database Links
Subcellular Location
Chromosome.
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