RING1A Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-Order)
Synonyms
RING1A antibody; RF434 antibody; At5g44280 antibody; K9L2.3 antibody; Putative E3 ubiquitin-protein ligase RING1a antibody; EC 2.3.2.27 antibody; Polycomb complex protein RING1a antibody; Protein RING1a antibody; AtRING1a antibody; RING-type E3 ubiquitin transferase RING1a antibody; Ring finger protein 434 antibody
Target Names
RING1A
Uniprot No.
Target Background
Function
RING1A is a putative E3 ubiquitin-protein ligase that mediates the monoubiquitination of histone H2A at lysine 119 (H2AK119ub). This activity plays a critical role in histone code regulation and gene expression. As a component of the PRC1-like complex, RING1A represses class I KNOX gene expression. The Polycomb Repressive Complex 1 (PRC1) maintains the transcriptionally repressive state of numerous genes, including Hox genes, throughout development. This repression is achieved through chromatin remodeling and histone modification, resulting in heritable changes in gene expression.
Gene References Into Functions
PMID: 24553292, RING1A suppresses MAF4 and MAF5 expression by modulating H3K27me3 levels at their loci, thereby regulating the floral transition., .
PMID: 21060339, Elevated AtRING1a levels are observed in the *Atbmi1a Atbmi1b* mutant, suggesting a self-regulatory feedback mechanism., .
PMID: 21060339, Elevated AtRING1a levels are observed in the *Atbmi1a Atbmi1b* mutant, suggesting a self-regulatory feedback mechanism., .
Database Links
KEGG: ath:AT5G44280
UniGene: At.30083
Subcellular Location
Nucleus.
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