ROPGEF1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ROPGEF1 antibody; At4g38430 antibody; F22I13.200 antibody; Rop guanine nucleotide exchange factor 1 antibody; AtRopGEF1 antibody; Kinase partner protein-like antibody; KPP-like antibody; Rho of plants guanine nucleotide exchange factor 1 antibody
Target Names
ROPGEF1
Uniprot No.
Target Background
Function
ROPGEF1 is a guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases. It promotes the exchange of GDP for GTP, thus activating the Rop GTPases. ROPGEF1 plays a crucial role in plant development by regulating various cellular processes, including:
- Polarized pollen tube growth: ROPGEF1 functions downstream of PRK2 in controlling the polarized growth of pollen tubes by activating ARAC11/ROP1.
- Stomatal closure: In conjunction with ROPGEF4, ROPGEF1 acts as a specific regulator of ARAC10/ROP11 function in abscisic acid (ABA)-mediated stomatal closure.
- Root hair development: ROPGEF1 may be involved in the Rac/Rop-signaling pathway that controls reactive oxygen species (ROS)-mediated root hair development.
Gene References Into Functions
- ROPGEF1 is essential for AUX1 localization and PIN differential accumulation, highlighting its role in cell polarity and polar auxin transport. This function impacts auxin-mediated plant growth and development. PMID: 28698357
- PP2C protein phosphatases protect and stabilize ROPGEF1 from abscisic acid (ABA)-mediated degradation. ROPGEF1 is epistatic to PP2C phosphatases in the ABA signal transduction pathway. Notably, ROPGEF1 plays a critical role in ABA-mediated inhibition of lateral root growth. PMID: 27192441
Database Links
Subcellular Location
Cytoplasm, cytosol. Cell membrane.
Tissue Specificity
Expressed in roots, cotyledons, leaves, stems, sepals, petals, anthers, pollen grains, stigmas and siliques.
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