RXRA Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receiving them. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery information.
Synonyms
FLJ00280 antibody; FLJ00318 antibody; FLJ16020 antibody; FLJ16733 antibody; MGC102720 antibody; NR2B1 antibody; Nuclear receptor subfamily 2 group B member 1 antibody; OTTHUMP00000022510 antibody; Retinoic acid receptor RXR alpha antibody; Retinoic acid receptor RXR-alpha antibody; Retinoid X nuclear receptor alpha antibody; Retinoid X receptor alpha antibody; RXR alpha1 antibody; Rxra antibody; RXRA_HUMAN antibody; RXRalpha1 antibody
Target Names
Uniprot No.
Target Background
Function
Retinoid X receptor alpha (RXRA) is a nuclear receptor that functions as a transcription factor. It forms homodimers or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. RXRA/RAR heterodimers bind to retinoic acid response elements (RARE), composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, to modulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of a ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation, and transcriptional suppression. Upon ligand binding, the corepressors dissociate from the receptors, and coactivators are recruited, leading to transcriptional activation. RXRA serves as a common heterodimeric partner for several nuclear receptors, such as RARA, RARB, and PPARA. The RXRA/RARB heterodimer can act as a transcriptional repressor or activator, depending on the RARE DNA element context. The RXRA/PPARA heterodimer is essential for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. In collaboration with RARA, it positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells. RXRA acts as an enhancer of RARA binding to RARE DNA elements and may facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1. It promotes myelin debris phagocytosis and remyelination by macrophages. RXRA plays a role in attenuating the innate immune system in response to viral infections, potentially by negatively regulating the transcription of antiviral genes such as type I IFN genes. It is involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence.
Gene References Into Functions
- The rs11638944:C>G transversion exerts a cis-acting effect on the expression levels of LOXL1, mediated by differential binding of the transcription factor retinoid X receptor alpha and by modulating alternative splicing of LOXL1, eventually leading to reduced levels of LOXL1 mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome. PMID: 28534485
- RXRA SNPs are not associated with vitamin D status and multiple sclerosis. PMID: 30088172
- This review analyzes the non-genomic effects of RXRA in normal and tumor cells and discusses the functional differences based on RXRA protein structure (structure source: the RCSB Protein Data Bank). [review] PMID: 30093910
- The results showed that overexpression of RXRalpha was correlated with unfavorable prognosis, suggesting that RXRalpha may serve as a potential targeted therapeutic marker in the treatment of Esophageal carcinoma (EC). PMID: 29661715
- We found that RXRalpha was upregulated in head and neck squamous cell carcinoma. PMID: 29228308
- Single nucleotide polymorphism rs11185644 near the RXRA was significantly associated with 25-Hydroxyvitamin D dose-response. PMID: 28079136
- Variability in the methylation status of the RXRalpha promoter near the EGR transcription factor binding site in newborn cord blood provides controversial epigenetic insights into RXRalpha regulation via EGR proteins. PMID: 29305749
- Loss of RXRA is associated with Non-Small Cell Lung Cancer. PMID: 28923935
- These findings unveil RXRalpha as an important cellular factor in modulating HBV infection and may point to a new strategy for host-targeted therapies against HBV. PMID: 29437960
- RXRalpha regulates HBV replication in and minichromosome remodeling. PMID: 28611266
- Findings indicate that Gc globulin (GC) rs16847024, retinoid X receptor gamma (RXRG) rs17429130, and retinoid X receptor alpha (RXRA) rs4917356 were candidate susceptibility markers for gestational diabetes mellitus (GDM) in Chinese females. PMID: 27636996
- This suggests that hRXRalpha phosphorylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclear trafficking, and binding to chromatin of the hVDR-hRXR complex. PMID: 27852823
- The expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1alpha,25-dihydroxyvitamin D3-induced upregulation of CAMP. PMID: 27357804
- IL-1beta upregulated RXRalpha through activation of NF-kappaB signaling. PMID: 26898458
- RXRA rs10776909 allele T is specifically involved in the pathogenesis of ChGN. This risk allele may also be associated with a worse clinical course of ChGN. PMID: 26610845
- Results suggest that retinoid X receptor (RXR) activation protects retinal pigment epithelium (RPE) cells from oxidative stress-induced apoptosis. PMID: 26883505
- Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively. PMID: 26355550
- Retinoid X receptor alpha plays an important role in the proliferation of cholangiocarcinoma. PMID: 26310932
- Data suggest a potential therapeutic role for the low toxicity synthetic retinoid X receptor selective agonist, UAB30, in neuroblastoma treatment. PMID: 25944918
- Studied the role of RXRalpha in downregulating hepatic detoxification during inflammation elicited by circulating cytokines. PMID: 26727233
- These findings define rules guiding how nuclear receptors integrate two ligand-dependent signaling pathways into RXR heterodimer-specific responses. PMID: 26289479
- Results reveal the retinoid X receptor pathway as a positive regulator of myelin debris clearance and a key player in the age-related decline in remyelination. PMID: 26463675
- DW22 antitumor agent upregulates RXRa and downregulates histone deacetylase in lung cancer and breast cancer tissues and cell lines. PMID: 25762635
- Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. PMID: 26644513
- A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha from retinoid X receptor to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart. PMID: 26443578
- Genetic association study in population in France: Data suggest 2 genetic polymorphisms (RXRA, rs7861779; VDR Fok1 [vitamin D receptor Fok1], rs2228570) are associated with cancers related to tobacco use and vitamin D status. PMID: 26447153
- Interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma. PMID: 25738607
- SUMOylation of RXRalpha is significantly enhanced through PIAS4-mediated activity. PMID: 26116533
- RXRA DNA-binding domain binds to DNA both as a monomer and as a homodimer, and the mechanism of binding is salt dependent and occurs in two steps. PMID: 24824382
- The ligand-dependent splicing activity of Acinus is related to the retinoic acid-activated retinoic acid receptor. PMID: 25205379
- EGCG and IIF cotreatment Cytotoxicity was related to upregulation of 67-kDa laminin receptor (LR67), one of the principal molecular targets of EGCG, and activation of the nuclear retinoic X receptors (RXRs) pathway. PMID: 25013807
- These observations suggest that beta-apo-13-carotenone regulates RXRalpha transcriptional activity by inducing the formation of the "transcriptionally silent" RXRalpha tetramer. PMID: 25324544
- Data show that disrupting the steroid receptor coactivator-1 (SRC1) binding site on retinoid X receptor alpha (RXRalpha) alters the transactivation by CAR:RXR. PMID: 25053412
- Elevated methylation at the RXRA promoter may be responsible for the downregulated mRNA expression in the right ventricular outflow tract myocardium of patients with tetralogy of Fallot. PMID: 24513686
- Drupanin, a component of BGP, is a novel RXR agonist with slight PPARgamma agonistic activity. PMID: 24972164
- The polymorphisms investigated in PPARA (rs1800206), RXRA (rs11381416), and NR1I2 (rs1523130) did not influence the lipid-lowering efficacy and safety of statin, and our results show the possible influence of NR1I3 genetic variant on the safety of statin. PMID: 24232815
- Retinoid X receptor alpha in human liver is regulated by miR-34a. PMID: 24832862
- Low retinoid X receptor alpha expression is associated with colon cancer progression. PMID: 24080207
- Structural analysis of human retinoid X receptor alpha-liver X receptor beta (RXRalpha-LXRbeta) heterodimer on its cognate element, an AGGTCA direct repeat spaced by 4 nt. PMID: 24561505
- Data show the networks of interactions that connect retinoid X receptor alpha (RXRalpha) agonists to coactivator GRIP1 binding. PMID: 24187139
- MiR-128-2 inhibits the expression of ABCA1, ABCG1, and RXRalpha directly through a miR-128-2-binding site within their respective 3'untranslated regions. PMID: 23990020
- Inflammatory signaling pathways rapidly induce SUMOylation of RXRalpha. PMID: 23690070
- SNPs in the CYP24A1, CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA), and megalin (LRP2) genes were significantly associated with pancreas cancer risk. PMID: 23826131
- These structures establish that PXR and RXRalpha form a heterotetramer unprecedented in the nuclear receptor family of ligand-regulated transcription factors. PMID: 23602807
- Retinoid acid receptor expression is helpful to distinguish between adenoma and well-differentiated carcinoma in the thyroid. PMID: 23639973
- Data demonstrate that GSK-3beta plays an important role in regulating tRXRalpha production by calpain II in cancer cells. PMID: 23389291
- RXRalpha diminishes cytoprotection by NRF2 by binding directly to the newly defined Neh7 domain in NRF2. PMID: 23612120
- Polymorphisms in the RXRA and NR1I3 genes influence lipid profile in a Southern Brazilian population. PMID: 23079705
- Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner. PMID: 23392891
- Single nucleotide polymorphisms in the RXRA and PLAUR genes in the vitamin D pathway may contribute to breast cancer disease-free survival. PMID: 23180655
Database Links
Protein Families
Nuclear hormone receptor family, NR2 subfamily
Subcellular Location
Nucleus. Cytoplasm. Mitochondrion.
Tissue Specificity
Expressed in lung fibroblasts (at protein level). Expressed in monocytes. Highly expressed in liver, also found in kidney and brain.
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