rxrba Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
rxrba antibody; nr2b2a antibody; rxrb antibody; rxre antibody; Retinoic acid receptor RXR-beta-A antibody; Nuclear receptor subfamily 2 group B member 2-A antibody; Retinoid X receptor beta-A antibody
Target Names
rxrba
Uniprot No.
Target Background
Function
The Retinoid X Receptor alpha (RXRα) is a nuclear receptor that plays a crucial role in regulating gene expression. It forms heterodimers with other nuclear receptors, such as Retinoic Acid Receptors (RARs), and binds to retinoic acid response elements (RAREs) in DNA. Upon ligand binding, RXRα/RAR heterodimers activate target gene transcription. The primary ligand for RXRα is 9-cis retinoic acid. These heterodimers bind to RAREs composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. RXRα is involved in various biological processes including cell growth, differentiation, and development.
Database Links
Protein Families
Nuclear hormone receptor family, NR2 subfamily
Subcellular Location
Nucleus.
Tissue Specificity
Shows uniform expression from the blastula to mid-gastrula stages. At 12 hours post-fertilization (hpf), expressed ubiquitously but more weakly. At 24 hpf, restricted to the ventral diencephalon, pharangeal endoderm and trunk and tail mesoderm; mesoderm e
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