S100A7 Antibody

S100A7 Antibody - Target Background

S100A7, also known as psoriasin, is a calcium-binding protein involved in various cellular processes, particularly in skin and epithelial tissues. Research has highlighted its diverse roles in:

• Inflammation and Immunity: S100A7 contributes to inflammatory responses in the skin, particularly in psoriasis, and has antimicrobial properties. It is also implicated in allergic rhinitis and trachomatous conjunctival scarring.
• Cancer Progression: S100A7 has been linked to the progression of various cancers, including breast cancer, lung cancer, and gastric cancer. It promotes cell proliferation, migration, invasion, and metastasis, making it a potential target for cancer therapies.
• Differentiation and Development: S100A7 plays a role in epithelial cell differentiation and has been implicated in the pathogenesis of psoriasis. It also exhibits tumor-suppressive effects in estrogen receptor-positive breast cancer cells.
• Other Functions: Studies suggest that S100A7 is involved in the regulation of cell-matrix adhesion, extracellular matrix production, and cytokine signaling.

The following research publications provide further insights into the specific functions and implications of S100A7:

1. Higher levels of psoriasin expression were significantly associated with a lack of response to neoadjuvant chemotherapy in patients with gastric cancer (GC). Psoriasin overexpression tended to decrease the sensitivity of GC cells to cisplatin, potentially by inhibiting apoptosis or increasing the S-phase population. PMID: 29956751
2. Study results suggest that OLFM4, LY6D and S100A7 immunoreactivity are associated with an aggressive phenotype of estrogen receptor (ER)-positive breast carcinoma, and these are potent markers for distant metastasis of ER-positive breast cancer patients. PMID: 30137688
3. As a regulator of epithelial ovarian cancer (EOC) cell proliferation, metastasis, and chemoresistance, S100A7 represents a potential prognostic biomarker for EOC as well as a treatment target. Because miR-330-5p functions as an inhibitor of EOC cell growth and S100A7 expression, it promises to improve EOC outcomes. PMID: 29485916
4. Data reveal a crucial role for S100A7 in regulating cell migration, invasion, metastasis and EMT of cervical cancer. PMID: 28212564
5. Study demonstrates for the first time that S100A7 not only functions as a facilitator of adenous-squamous carcinoma phenotypic transition in lung cancer cells but also that its expression is differentially regulated by the Hippo-YAP pathway. PMID: 28177901
6. Findings demonstrate for the first time that S100A7 is repressed by YAP via the Hippo pathway. PMID: 27203549
7. In this paper, we reviewed the emerging roles of S100A7 in the pathogenesis of psoriasis. In particular, we focus on the psoriatic cytokine network where S100A7 is involved. Finally, we discuss the possible use of S100A7 as therapeutic target in psoriasis. PMID: 26872860
8. The promigratory function of S100A7 on tumor cells was confirmed in A431 cells where neutralizing monoclonal antibodies were able to block this effect. PMID: 28825725
9. a set of IL-17A-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A, S100A7, IL19 and CSF3, based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A. PMID: 26944069
10. Psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis. PMID: 27958610
11. only S100A7ox exhibits antibacterial activity against select bacterial species. Metal substitution experiments suggest that the disulfide bonds in S100A7 may enhance metal sequestration by the His3Asp sites and thereby confer growth inhibitory properties to S100A7ox. PMID: 28976190
12. A significant increase of salivary psoriasin was observed in Systemic sclerosis patients when compared with other healthy and pathological controls. PMID: 27608975
13. our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis. PMID: 28060905
14. higher expression of Psoriasin was associated with local invasion in pancreatic cancers. Psoriasin expression is associated with pancreatic cancer cell growth, migration, cell-matrix adhesion, and invasion via regulation of MMPs PMID: 28393239
15. S100A7 induction by the Hippo-YAP pathway in cervical and glossopharyngeal squamous cell carcinoma has been described. PMID: 27907036
16. The expression of inflammatory markers in the conjunctiva of trachomatous trichiasis patients were studied; CTGF, S100A7, and IL-1beta were all increased. PMID: 27249027
17. S100 calcium-binding protein A7 (S100A7) overexpression was demonstrated in the plaques of patients with psoriasis vulgaris with joint inflammation, compared with those without joint involvement. PMID: 27573000
18. rs3014837 polymorphism associated with calcium level in serum of psoriasis patients PMID: 26173840
19. The presence of S100A7 in the Fallopian tube and its localization at the apical surface of epithelial cells PMID: 24152708
20. overexpression of S100A7 in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 and caspase-14 PMID: 25651379
21. S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation of squamous cell carcinomas. PMID: 26053695
22. The distinct modulations of the NF-kappaB - miR-29b - p53 pathway make S100A7 an oncogene. PMID: 25622979
23. S100A7 also promotes secretion of IL-6 and IL-8. PMID: 24671027
24. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts PMID: 25502330
25. decreased expression in nasal epithelia of allergic rhinitis patients PMID: 25514480
26. Our present results suggest that S100A7 level is a promising tool for diagnosis of lung squamous cell carcinoma. Knockdown of S100A7 suppresses lung cancer growth PMID: 25550886
27. present a novel signalling mechanism by which IL-17A can induce Egr-1-dependent psoriasin expression via the ERK pathway in keratinocytes PMID: 25256120
28. found that RAGE/S100A7 conditioned the tumor microenvironment by driving the recruitment of MMP9-positive tumor-associated macrophages PMID: 25572331
29. The antimicrobial peptide psoriasin has immunoregulatory activities and is involved in skin innate immunity. PMID: 24842328
30. Data indicate that aberrant expression of psoriasin is implicated in prostate cancer (CaP). PMID: 22694938
31. visfatin enhances CAMP, hBD-2, hBD-3, and S100A7 production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin. PMID: 23499548
32. S100A7 overexpression is associated with high risk of malignant transformation in oral dysplasia. PMID: 24122701
33. S100A7 enhances metastasis in estrogen receptor alpha-negative breast cancer cells through regulation of actin cytoskeleton and MMP-9 secretion. PMID: 23535840
34. High S100A7 enhances invasion of breast cancer through activation of nuclear factor-kappaB signaling. PMID: 23618129
35. Levels of psoriasin, RNase 7 and hBD-3 expression - assessed by immunohistochemistry - varied between different body localisations. PMID: 23614747
36. Psoriasin plays crucial roles in regulating the growth and invasion of lung cancer cells. PMID: 23228205
37. expression of psoriasin is linked to the luminal differentiation marker CD24 in mammary epithelial cells. Psoriasin had a role in the shift towards a differentiated CD24(+) phenotype, suggesting a role in the differentiation of mammary epithelial cells. PMID: 23300877
38. Each S100A7 isoform is involved in critical phases of the breast cancer growth and progression PMID: 22641350
39. Psoriasin is a novel biomarker for, and the first to confirm the link between obesity and psoriasis. PMID: 23151615
40. Increased S100A7 expression was associated with trachomatous conjunctival scarring and may be linked to the pathophysiology of recurrent trachomatous trichiasis. PMID: 23285311
41. Psoriasin may play a role in the pathogenesis of mycosis fungoides by stimulating chemotaxis of CD4+ T lymphocytes. PMID: 22126777
42. Expression of psoriasin appears to be reduced in CFBE410-negative cells compared to 16HBE14o- cells; its expression treatment-wise is modified by exposure to pro-inflammatory cytokines. PMID: 22772316
43. Letter: Report IL-36-mediated psoriasin and LL-37 production in keratinocytes via MAPK/NFkappaaB pathway. PMID: 22901663
44. Psoriasin (S100A7) promotes migration of a squamous carcinoma cell line PMID: 22795619
45. psoriasin expression in mammary epithelial cells leads to increased endothelial cell proliferation in a paracrine manner through the receptor for advanced glycation end products. PMID: 22189627
46. report the presence of S100A7 in human sperm and of a homologous protein in pig, with similar localisations PMID: 22220760
47. The study showed an epithelial expression and excretion of S100A7 in the nose after microbial stimulation. The levels were diminished in rhinitis patients and in the presence of an allergic cytokine milieu. PMID: 22230654
48. Recent studies point to an important role of psoriasin as an antimicrobial and immunomodulatory protein in skin and other epithelia. PMID: 21501383
49. Data show that hS100A7 and mS100a7a15 overexpression induce proliferation and expression of inflammatory cytokines/chemokines. PMID: 22158945
50. Tumor-suppressive effects of psoriasin (S100A7) are mediated through the beta-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells. PMID: 22016394

HGNC: 10497

OMIM: 600353

KEGG: hsa:6278

STRING: 9606.ENSP00000357711

UniGene: Hs.112408