S1PR5 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery times may vary depending on the purchase method and location. Please contact your local distributor for specific delivery time information.
Synonyms
S1PR5; EDG8; Sphingosine 1-phosphate receptor 5; S1P receptor 5; S1P5; Endothelial differentiation G-protein-coupled receptor 8; Sphingosine 1-phosphate receptor Edg-8; S1P receptor Edg-8
Target Names
Uniprot No.
Target Background
Function
S1PR5 acts as a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that exerts diverse physiological effects on most cell and tissue types. S1PR5 couples with both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. It may play a regulatory role in the transformation of radial glial cells into astrocytes and potentially affects the proliferative activity of these cells.
Gene References Into Functions
- Reduced DNA methylation may contribute to the increased expression of the S1PR5 gene in alveolar macrophages, potentially leading to impaired efferocytosis in chronic obstructive pulmonary disease (COPD). PMID: 27868302
- Research indicates that the mitotic kinase Polo-like kinase 1 (PLK1) serves as a critical effector of S1P-S1P5 signaling. This suggests a novel function of the SphK1-S1P pathway specifically in controlling mitosis within HeLa cells. PMID: 28351953
- TGF-beta2-dependent upregulation of S1P5 is necessary for the induction of pro-fibrotic connective tissue growth factor (CTGF) by TGF-beta in mesangial cells. PMID: 25601519
- This study highlights a reduction in S1P5 expression within multiple sclerosis lesions, which parallels the loss of myelin. PMID: 23551178
- Findings indicate that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 are expressed in primary, recurrent, and secondary glioblastomas. Notably, sphingosine kinase SphK2 levels were highest in primary tumors. PMID: 24903384
- The Edg-5 receptor in brain endothelial cells contributes to optimal barrier formation and the maintenance of immune quiescence in the barrier endothelium. PMID: 22715976
- Decreased expression of S1PR5 on natural killer (NK) cells has been linked to the occurrence of graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. PMID: 22541110
- The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been extensively characterized. PMID: 11705398
- Differences between human S1P(5) and rat S1P(5) are crucial considerations in the development of selective receptor antagonists. PMID: 12234605
- Research efforts have focused on identifying and characterizing the gene, describing its expression in normal tissues and large granular lymphocyte leukemia monocytes. PMID: 12427546
- FTY720 induces time-dependent modulation of S1P receptors on human oligodendrocyte precursor cells (OPCs), resulting in functional responses directly relevant to the remyelination process. PMID: 17918267
- The centrosomal sphingosine-1-phosphate receptor 5 might act as an intracellular target of sphingosine-1-phosphate, potentially regulating mitosis. PMID: 19211033
- Under serum-starved conditions, sphingosine 1-phosphate (S1P) further upregulates autophagic activity through S1P(5)-dependent pathways in PC-3 cells. PMID: 19474291
Database Links
Protein Families
G-protein coupled receptor 1 family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overex
Customer Reviews
,
B.A
By Anonymous
★★★★★
Applications : Western Blot (WB)
Sample type: cell
Review: The proteins of SPHK1, S1PR5, PPAR-α, and PPAR-γ were detected by Western blot in brain tissue, and the relative expression of SPHK1, S1PR5, PPAR-α, and PPAR-γ was statistically analyzed.
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