slc25a48 Antibody

Research Findings on SLC25A48 Function

Recent studies highlight SLC25A48’s role in mitochondrial choline metabolism:

• Choline Transport: SLC25A48 facilitates mitochondrial choline import, enabling synthesis of betaine (a one-carbon metabolism intermediate) and purine nucleotides .

• Bioenergetics: Loss of SLC25A48 impairs mitochondrial respiration, increases oxidative stress, and disrupts membrane integrity .

• Cancer Metabolism: SLC25A48-deficient cancer cells exhibit reduced choline uptake and impaired proliferation .

Applications in Research

The antibody is used to study:

• Protein localization: Confirms mitochondrial localization via Western blot and immunofluorescence .

• Knockout validation: Validates SLC25A48 loss in gene-edited cell models .

• Cancer biology: Investigates SLC25A48’s role in tumor metabolism .

Tissue Expression and Orthologs

SLC25A48 is expressed in diverse tissues, including:

• Adipose tissue: High expression in brown fat .

• Liver: Central to choline metabolism .

• Brain: Detected in cerebral cortex and hippocampus .

Orthologs exist in mouse, rat, zebrafish, and chimpanzee, facilitating cross-species studies .

Clinical Implications

Rare loss-of-function variants in SLC25A48 are linked to:

• Musculoskeletal disorders (e.g., muscle weakness) .

• Digestive diseases (e.g., gastrointestinal dysfunction) .