selenok Antibody

Introduction to SELENOK Antibody

SELENOK antibodies are immunodetection reagents designed to bind specifically to selenoprotein K, a 94-amino-acid protein with a molecular weight of 10.6 kDa. SELENOK is highly expressed in immune cells and plays non-enzymatic roles in post-translational modifications, such as palmitoylation, by stabilizing the DHHC6 acyltransferase enzyme . These antibodies enable researchers to investigate SELENOK's involvement in calcium flux, T-cell activation, and antiviral immunity .

Biological Functions of SELENOK

SELENOK regulates critical immune processes:

• Calcium Signaling: Facilitates store-operated calcium entry (SOCE) in T cells, neutrophils, and macrophages by palmitoylating IP3R, a calcium channel protein .

• Antiviral Immunity: Enhances STING oligomerization in the ER, promoting interferon (IFN) production during DNA virus infections like HSV-1 .

• Redox Regulation: Supports ER stress responses and redox quality control of immunoglobulins .

Key Research Findings Using SELENOK Antibodies

Recent studies leveraging SELENOK antibodies include:

Table 1: Key Research Applications

Recent Advances and Clinical Relevance

• Viral Defense: SELENOK-deficient mice showed 50% mortality during HSV-1 infection due to impaired IFN responses .

• Autoimmunity: Polymorphisms in SELENOK-related pathways are linked to inflammatory diseases .