SEPT8 Antibody
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In Stock 
Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on the purchasing method and location. Please consult your local distributors for specific delivery timeframes.
Synonyms
SEPTIN8 antibody; KIAA0202 antibody; SEPT8 antibody; Septin-8 antibody
Target Names
SEPT8
Uniprot No.
Target Background
Function
SEPT8 is a filament-forming cytoskeletal GTPase. It may play a role in platelet secretion and appears to be involved in the process of SNARE complex formation in synaptic vesicles. SEPT8 stabilizes BACE1 protein levels and promotes its sorting and accumulation in recycling or endosomal compartments, ultimately modulating the beta-amyloidogenic processing of APP.
Gene References Into Functions
- SEPT8 modulates beta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1. PMID: 27084579
- Cloning, overexpression, purification and preliminary characterization of human septin 8. Fluorescence emission spectra, analytic gel filtration and DLS reflect the sample oligomeric heterogeneity with the predominance of dimers in solution. PMID: 20544379
- SEPT8 and SEPT4 are localized surrounding alpha-granules. Activation of platelets by agonists resulted in the translocation of SEPT4 and SEPT8 to the platelet surface indicating a possible functional role of these proteins in platelet granular secretion. PMID: 15116257
- We studied the assembly of three human septins, SEPT4, SEPT5 and SEPT8, with each other (heterotypic) and with themselves (homotypic) using a yeast two-hybrid system. PMID: 15214843
- Our findings suggest a role for members of the septin family in the development of proliferative retinal membranes. PMID: 17625225
Database Links
Protein Families
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, presynapse.
Tissue Specificity
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in speci
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