SH2D1B Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. For specific delivery times, please consult your local distributor.
Synonyms
SH2D1B antibody; EAT2 antibody; SH2 domain-containing protein 1B antibody; EWS/FLI1-activated transcript 2 antibody; EAT-2 antibody
Target Names
Uniprot No.
Target Background
Function
SH2D1B Antibody is a cytoplasmic adapter protein that regulates receptors of the signaling lymphocytic activation molecule (SLAM) family, including CD84, SLAMF1, LY9, and CD244. In SLAM signaling, SH2D1B appears to collaborate with SH2D1A/SAP. It plays a role in regulating effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without affecting its tyrosine phosphorylation. Downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not influence receptor tyrosine phosphorylation but does affect distal signaling. In the context of NK cell-mediated cytotoxicity, SH2D1B does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. SH2D1B negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors, likely by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation.
Gene References Into Functions
- When compared to SAP, the other single SH2 domain protein in humans, EAT2 exhibits similar binding energies to unphosphorylated ligands. This finding contradicts previous data suggesting low affinity of EAT2 toward unphosphorylated peptides compared to SAP, which demonstrates high affinity. PMID: 27586300
- Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) overexpression increases the anti-tumor activity of NK cells against K562 tumor cell targets. PMID: 24374770
- EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase. PMID: 24687958
Database Links
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