SH3BGRL3 Human
Description
Introduction to SH3BGRL3
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) is a 93-amino-acid protein encoded by the SH3BGRL3 gene located on chromosome 1p36.11 . It belongs to the SH3BGR gene family, which includes SH3BGR, SH3BGRL, SH3BGRL2, and SH3BGRL3. Structurally, SH3BGRL3 shares homology with bacterial glutaredoxin-1 but lacks enzymatic redox activity, suggesting a regulatory role in redox signaling .
Gene Structure
Protein Features
| Property | Detail |
|---|---|
| Molecular Weight | ~10.5 kDa |
| Isoelectric Point | 5.0 |
| Domains | SH3-binding domain, glutamic acid-rich region |
| Post-Translational Modification | Identified as TNF-α inhibitory protein TIP-B1 |
Expression and Distribution
SH3BGRL3 exhibits broad tissue expression but is enriched in smooth muscle cells and subsets of immune cells . Key findings include:
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Cancer Overexpression: Elevated in acute myeloid leukemia (AML), gastric cancer (GC), and glioblastoma .
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Normal Tissues: Detected in bone marrow, spleen, and lymph nodes .
Table 1: SH3BGRL3 Expression in Human Tissues
| Tissue | Expression Level | Source |
|---|---|---|
| Bone Marrow | High | Protein Atlas |
| Smooth Muscle | Moderate-High | Protein Atlas |
| Immune Cells | Moderate | Protein Atlas |
Functional Roles and Mechanisms
SH3BGRL3 regulates cellular processes through interactions with cytoskeletal and signaling proteins:
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Cytoskeleton Regulation: Binds actin-associated proteins (e.g., profilin-1, cofilin-1) to modulate cytoskeletal dynamics .
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Cancer Progression:
Key Molecular Pathways
Therapeutic Target
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circSH3BGRL3 Knockdown: Reduces AML cell proliferation by 40% and induces cell-cycle arrest .
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Immune Microregulation: Downregulates CD4+ T and NK cells, contributing to immune evasion .
AML Study Highlights
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CircRNA_0010984: Upregulated in AML patient samples (fold change = 3.2 vs. controls) .
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Mechanism: Acts as a competing endogenous RNA (ceRNA) to elevate YAP1, promoting leukemogenesis .
Gastric Cancer Insights
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Metabolic Reprogramming: SH3BGRL3-high tumors show enriched oxidative phosphorylation (OXPHOS) pathways (P < 0.01) .
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Blood Glucose Link: High SH3BGRL3 correlates with hyperglycemia (blood glucose >6.1 mmol/L, P = 0.0096) .
Interacting Partners
Product Specs
Product Science Overview
SH3 Domain Binding Glutamic Acid-Rich Protein Like 3 (SH3BGRL3) is a protein encoded by the SH3BGRL3 gene in humans. This protein is part of the SH3BGR family, which includes small proteins that share similarities with the N-terminal region of the SH3BGR protein. SH3BGRL3 is a protein-coding gene and is known for its involvement in various biological processes and potential implications in diseases.
The SH3BGRL3 gene is located on chromosome 1 at the position 1p36.11 . The protein encoded by this gene has a molecular weight of approximately 10.5 kDa and an isoelectric point of 5.0 . SH3BGRL3 shows significant similarity to glutaredoxin 1 of E. coli, and it is predicted to belong to the thioredoxin-like protein family .
Although the precise function of SH3BGRL3 is not fully understood, it is believed to act as a modulator of glutaredoxin biological activity . It may also play a role in cytoskeleton organization . SH3BGRL3 lacks the enzymatic function of glutaredoxins but may serve as a regulator of redox activity .
SH3BGRL3 has been associated with several diseases, including Three M Syndrome 1 and Myeloproliferative Neoplasm . It has also been found to be overexpressed in various tumors, such as glioblastoma multiforme and acute promyelocytic leukemia . The protein’s upregulation in these cancers suggests a potential role in tumorigenesis and cancer progression.
SH3BGRL3 has been shown to bind to myosin 1c in a calcium-dependent manner, indicating a possible role in modulating cytoskeletal dynamics . Additionally, recent studies suggest a relationship between SH3BGRL3 and members of the EGFR family, which are known to be involved in cell signaling and cancer .
