SH3BP1 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery time estimates.
Synonyms
3BP 1 antibody; 3BP-1 antibody; 3BP1_HUMAN antibody; ARHGAP43 antibody; dJ37E16 antibody; FLJ21318 antibody; OTTHUMP00000028981 antibody; SH3 domain binding protein 1 antibody; SH3 domain-binding protein 1 antibody; Sh3bp1 antibody
Target Names
SH3BP1
Uniprot No.
Target Background
Function
SH3BP1 is a GTPase activating protein (GAP) that specifically converts GTP-bound Rho-type GTPases, including RAC1 and CDC42, into their inactive GDP-bound forms. By specifically inactivating RAC1 at the leading edge of migrating cells, SH3BP1 regulates the spatial and temporal organization of cell protrusions, which is crucial for proper cell migration. It also negatively regulates CDC42 in the processes of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity towards RAC1 and/or CDC42, SH3BP1 plays a specific role in phagocytosis of large particles. It is specifically recruited by a PI3 kinase (PI3K)-dependent mechanism to sites of large particle engagement, where it inactivates RAC1 and/or CDC42, enabling the reorganization of the underlying actin cytoskeleton required for engulfment. Additionally, SH3BP1 plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E, SH3BP1 dissociates from PLXND1 and inactivates RAC1, inducing intracellular reorganization of the actin cytoskeleton and cell collapse.
Gene References Into Functions
- Research has demonstrated a high SH3BP1 expression in cervical cancer tissues, which correlates with a shorter overall survival. Its expression is even higher in cisplatin-resistant cervical neoplasm tissues compared to cisplatin-sensitive ones. Furthermore, SH3BP1 plays a significant role in regulating cervical cancer cell invasion, migration, and chemoresistance through Rac1/Wav2. PMID: 28786507
- Splicing of the SH3BP1 and CIN gene loci produces a novel brain-specific splice variant called BGIN. PMID: 23223568
- Epithelial junction formation and morphogenesis require a dual-activity complex containing SH3BP1 and CapZ, which is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics. PMID: 22891260
Database Links
Subcellular Location
Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol.
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