SH3BP4 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery times may vary based on the purchasing method or location. For specific delivery times, please consult your local distributors.
Synonyms
BOG25 antibody; EH binding protein antibody; EH binding protein 10 antibody; EH-binding protein 10 antibody; EHB10 antibody; SH3 domain binding protein 4 antibody; SH3 domain-binding protein 4 antibody; SH3B4_HUMAN antibody; sh3bp4 antibody; Transferrin receptor trafficking protein antibody; Transferrin receptor-trafficking protein antibody; TTP antibody
Target Names
SH3BP4
Uniprot No.
Target Background
Function
SH3BP4 antibody may play a role in the internalization of the transferrin receptor at the plasma membrane by regulating clathrin-mediated endocytosis in a cargo-specific manner. Alternatively, it may act as a negative regulator of amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. SH3BP4 preferentially binds to inactive Rag GTPase complexes, preventing their interaction with the mTORC1 complex, thereby inhibiting its relocalization to lysosomes and subsequent activation. This mechanism potentially indirectly regulates cell growth, proliferation, and autophagy.
Gene References Into Functions
- SH3BP4 has been identified as a novel pigmentation gene. It is a direct target of miR-125b and is transcriptionally regulated by MITF as its direct target. PMID: 28819321
- SH3BP4 acts as a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling. PMID: 22575674
- Research indicates that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). PMID: 16325581
Database Links
Subcellular Location
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity
Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
