SHR Antibody

The SHORT ROOT (SHR) transcription factor is essential for the development of the plant root system. It plays a crucial role in quiescent center cell specification, maintenance of surrounding stem cells, and the asymmetric cell divisions underlying radial patterning. SHR is vital for both cell division and cell fate determination. Furthermore, it regulates the radial organization of shoot axial organs and is required for normal shoot gravitropism. SHR directly controls the transcription of SCARECROW (SCR) and, in conjunction with SCR, regulates the expression of several other genes including MGP, RLK, TRI, NUC, and SCL3.

Key Research Findings on SHR Function:

• ID Binding Sequences and SHR Regulation: INDETERMINATE DOMAIN PROTEIN (ID) binding sequences are critical for regulating SCARECROW (SCR) and SHORT ROOT (SHR) expression. (PMID: 28324206)
• SHR Cell-to-Cell Transport: The interaction between KinG and SHR facilitates the formation of stable protein complexes that enable the cell-to-cell movement of SHR. (PMID: 29122988)
• Functional Conservation of SHR: Arabidopsis thaliana SHR, and its rice orthologs OsSHR1 and OsSHR2, demonstrate functional complementation in the A. thaliana shr mutant. (PMID: 28263767)
• SHR as a Mobile Signal: All SHR proteins function as mobile signaling molecules. (PMID: 25352666)
• SHR and Cytokinin Homeostasis: SHR regulates vascular patterning through the control of cytokinin homeostasis, but does not appear to directly affect root apical meristem activity. (PMID: 22476466)
• Dose-Dependent Signaling: The SHORT ROOT protein acts as a mobile, dose-dependent signal in ground tissue patterning. (PMID: 22826238)
• SHR in Shoot Development: SHR functions in plant growth and development by regulating cell division and meristem activity in both roots and shoots. (PMID: 22194939)
• Cytokinin Regulation: One mechanism by which SHR controls vascular patterning is through the regulation of cytokinin homeostasis. (PMID: 21951467)
• Broad Developmental Roles: SHR regulates a wide array of Arabidopsis root-related developmental processes. (PMID: 21030506)
• Vascular Patterning: SHR plays a central role in root vascular system patterning, potentially regulated by longitudinal and radial signals. (PMID: 20680487)
• Cell Division Regulation: SHR regulates the spatiotemporal activation of genes involved in cell division. (PMID: 20596025)
• Root Maturation: SHR and SCR proteins are involved in the maturation of A. thaliana roots, including cell organization. (PMID: 15955927)
• Direct Targets of SHR: Studies have identified direct target genes of SHR through global gene expression profiling after modulating SHR activity. (PMID: 16640459)
• SHR Movement and Localization: SHR movement from the stele is crucial for proper root patterning, requiring multiple domains for movement and subcellular localization. (PMID: 19000160)

KEGG: ath:AT4G37650

STRING: 3702.AT4G37650.1

UniGene: At.2816