SIGLEC5 Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery times may vary depending on the purchase method and location. Please consult your local distributors for specific delivery information.
Synonyms
SIGLEC5; CD33L2; OBBP2; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD antigen CD170
Target Names
SIGLEC5
Uniprot No.
Target Background
Function
Siglec-5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally well to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Gene References Into Functions
- PSGL1 and Siglec-5 are closely positioned on the leukocyte surface. SPSGL1, a ligand for Siglec-5, interacts with the Siglec-5 ectodomain. Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general. PMID: 27892504
- An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 elicits an anti-inflammatory signal, while stimulation through Siglec-14 promotes inflammation. PMID: 26459514
- Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus. PMID: 24799499
- Studies have shown that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 as a co-receptor. PMID: 24068891
- These studies demonstrate that the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates, providing a foundation for further investigation of Siglec5 structure and function. PMID: 23321067
- Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death, contributing to the different outcomes of HIV-1 infection in humans and chimpanzees. PMID: 22945238
- Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. PMID: 21795693
- Siglec-5 expression correlates with a lack of proliferation in a subset of human cells and is upregulated by activation of chimpanzee but not human lymphocytes. PMID: 20231688
- Expression of Siglec-5 on cells of the myelomonocytic lineage and its modulation by inflammatory stimuli suggest a role for this protein in cell-cell interactions following microbial exposure. PMID: 12763136
- Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation. PMID: 15769739
- Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
- The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
- Siglec-14 and Siglec-5 appear to be the first glycan-binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5. PMID: 17012248
- Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils. PMID: 17675532
- Structural implications of SIGLEC5-mediated sialoglycan recognition are reported. PMID: 18022638
- Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival. PMID: 19596804
Database Links
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from
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