SIGMAR1 Antibody

1. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein, resulting in decreased levels of the ion channel protein and a reduction in TRPV1-associated pain. PMID: 29378958
2. Research indicates that sigma1R expression is decreased in hepatocellular carcinoma and is closely correlated with histological differentiation. PMID: 29399701
3. Mutations in the Sigma receptor-1 gene lead to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins. PMID: 28622300
4. Findings suggest that a loss of Sig1R function is causative for juvenile amyotrophic lateral sclerosis (ALS16), and collapse of the mitochondria-associated membrane is a common pathomechanism in both Sig1R- and SOD1-linked ALS. PMID: 27821430
5. Analysis of tissue microarrays from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Additionally, a cohort of 4937 breast cancer patients revealed a significant correlation between high expression of SigmaR1 and Orai1 channels and lower overall survival. PMID: 28114279
6. Data demonstrate that Sigma1 modulators can be used to suppress AR/ARV-driven prostate cancer cells through the regulation of pharmacologically responsive Sigma1-AR/ARV interactions, both in vitro and in vivo. PMID: 28235766
7. A genetic variant within the SIGMAR1 gene (rs1800866A>C) has been associated with Major Depressive Disorder and Bipolar Disorder. PMID: 28144920
8. Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction. This highlights the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology. PMID: 27402882
9. Changes in Sig1R and SOD2 expression suggest that mitochondria are the primary organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. These proteins are involved in the intracellular response to stress associated with varying oxygen concentrations. PMID: 27829319
10. The sigma-1 receptor and the nNav1.5 channel form a physical, functional complex. PMID: 27160185
11. Research collectively defines Sig1R as a key mediator of TRAIL-induced cancer-specific killing. PMID: 26792723
12. Crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP, have been determined. PMID: 27042935
13. Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity, and causes mitochondrial injury, ultimately aggravating ER stress-induced neuronal death. PMID: 25704016
14. Recent studies indicate that sigma-1 receptors, in part due to their unique subcellular localization, regulate mitochondrial function, involving bioenergetics and free radical generation. PMID: 25704011
15. Removal of the S1R gene in the Superoxide Dismutase-1 (SOD-1) mouse model of ALS exacerbated the neurodegenerative condition and resulted in significantly reduced longevity. PMID: 25704013
16. This review provides an overview of the biological mechanisms frequently associated with neurodegeneration and discusses how sigma-1 receptors may alter these mechanisms to preserve or restore neuronal function. PMID: 25704014
17. Mutations of the SIGMAR1 gene worsen the outcome in Alzheimer's disease and myotrophic lateral sclerosis, supporting a role for Sig-1R in neurodegenerative disease. PMID: 25704015
18. Blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects were examined regarding 10 single nucleotide polymorphisms (SNPs) in the APOD and SIGMAR1 genes to identify possible associations with IS risk, IS severity, and recovery after IS. PMID: 25261976
19. Central and peripheral pharmacological blockade of Sig-1R could be an effective option for treating inflammatory pain (review). PMID: 25902777
20. Results suggest that the ubiquitin-proteasome pathway is implicated in nuclear inclusion formation, and that SIGMAR1 degrades aberrant proteins in the nucleus via the endoplasmic reticulum-related degradation machinery. PMID: 25449906
21. A homozygous c.151+1G>T mutation in SIGMAR1 caused a novel form of autosomal recessive distal hereditary motor neuropathy (dHMN) in a Chinese consanguineous family; endoplasmic reticulum stress may play a role in the pathogenesis of dHMN. PMID: 26078401
22. Patients with hilar cholangiocarcinoma overexpressed Sig1R and had an earlier recurrence and worse overall survival than those not overexpressing Sig1R. PMID: 25344871
23. Data suggest that SIGMAR1 exists in vivo (in this case, as recombinant fusion proteins expressed in COS-7 cells) in multiple monomeric/dimeric/oligomeric forms and that SIGMAR1 ligands alter the distribution of SIGMAR1 within these structures/aggregates. PMID: 25510962
24. SIGMAR1 serves as an alternative upstream STAT3 activator in addition to the IL6/JAK signaling pathway. PMID: 24726897
25. A combination of AAG8 antagonist and a very low concentration of a MEK inhibitor synergistically restricts the growth of drug-resistant cells. PMID: 24634165
26. Results support the notion that loss of SigR1 function contributes to ALS pathology by causing abnormal ER morphology, lipid raft destabilization, and defective endolysosomal pathways. PMID: 24922074
27. The sigma-1 receptor may bind to hERG in the ER, assisting in its assembly and trafficking to the plasma membrane. PMID: 25266722
28. Causative mutations in the SIGMAR1 gene are rare in Korean patients with either familial or sporadic ALS. PMID: 24684794
29. SIGMAR1 may shuttle between the nucleus and the cytoplasm. PMID: 24313828
30. Data indicate that the mitochondrion-associated ER membrane (MAM) regulates cellular survival through an MAM-residing ER chaperone, the sigma-1 receptor (Sig-1R). PMID: 24204710
31. SIGMAR1 has been reported to be associated with juvenile amyotrophic sclerosis. A homozygous missense mutation, E102Q, in the SIGMAR1 gene was identified in autosomal recessive FALS from Saudi Arabia. PMID: 24085347
32. The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity. PMID: 24616099
33. The dual nature of Sig1R action, acting either pro- or antiapoptotic in specific conditions, likely depends on Sig1R activity resulting from its expression level. PMID: 23906352
34. This research explores the possible pathways by which the sigma-1 receptor may reduce motoneuron excitability, thereby playing a protective function during the progression of ALS. PMID: 24592734
35. The sigma-1 receptor binds to the GluN1/GluN2A NMDA receptor specifically via the GluN1 subunit. PMID: 24227730
36. Unfolded protein response (UPR) and autophagy are engaged as primary and secondary cytoprotective responses, respectively, to Sigma1 ligand-induced disruption of cancer cell protein homeostasis. PMID: 24006496
37. OPRS1 mediates IL-24-induced cancer-specific apoptosis. PMID: 23988449
38. The chaperone domain of S1R interacts with full-length BiP. PMID: 23760505
39. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 is not involved in the regulation of calcium signaling via TRPC5/TRPM3 channels (transient receptor potential cation channels C5/M3). PMID: 23121507
40. The sigma-1 receptor regulates early steps of hepatitis C viral RNA replication at the onset of infection. PMID: 23536676
41. Coding and noncoding variants located in the 3'-UTR region of the SIGMAR1 gene are not the cause of FTLD-MND in this cohort, and more than half of this targeted cohort is genetically explained by C9ORF72 repeat expansions. PMID: 22739338
42. This study demonstrates that sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens. PMID: 23041531
43. This study demonstrated an association between the SIGMAR1 Gln2Pro polymorphism and schizophrenia in the Japanese population. PMID: 22818711
44. Each set of six transmembrane regions in Nav1.5 likely constitutes a Sig1R binding site, suggesting that Sig1R interacts with the transmembrane regions of its binding partners. PMID: 22952230
45. Sig1R likely interacts with different domains of Kv ion channel family proteins, resulting in distinct modulation of different channels. PMID: 22433979
46. Our data demonstrates an association between the SIGMAR1 TT-P variant and the risk of developing Alzheimer's disease. PMID: 22561649
47. The sigma1R may serve as a potential predictive factor for pTNM classification and tumor development in esophageal squamous cell carcinoma. PMID: 22511599
48. The sigma-1 receptor plays a significant role in modifying the function of transmembrane proteases. PMID: 22322890
49. Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. PMID: 21680736
50. SIGMAR1 and APOE interact to influence Alzheimer's disease severity across ethnic populations. PMID: 21605063

Show More

Hide All

HGNC: 8157

OMIM: 601978

KEGG: hsa:10280

STRING: 9606.ENSP00000277010

UniGene: Hs.522087