Function
SRT2 is a NAD+-dependent protein deacylase that catalyzes the NAD+-dependent hydrolysis of acyl groups from lysine residues. It functions as a negative regulator of plant basal defense against pathogens, potentially through the suppression of salicylic acid biosynthesis.
Gene References Into Functions
- SRT2 plays a crucial role in the fine-tuning of mitochondrial energy metabolism. PMID: 24424322
- Arabidopsis thaliana SRT2 (AtSRT2) is a deacetylase that negatively regulates plant basal defense mechanisms and the expression of pathogenesis-related protein 1 (PR1). PMID: 20573705
Protein Families
Sirtuin family, Class II subfamily
Subcellular Location
Mitochondrion matrix. Nucleus.