SIRT6 Antibody

SIRT6's Role in Biological Processes

1. Research has elucidated the mechanism by which SIRT6 facilitates tumorigenesis and metastasis in colon cancer cells, suggesting its potential as a therapeutic target for treating this disease. PMID: 29227545
2. SIRT6 inhibits proliferation, migration, and invasion of colon cancer cells by upregulating PTEN expression and downregulating AKT1 expression. PMID: 29957460
3. SIRT6 potentially suppresses cell proliferation, migration, and invasion by inhibiting the NOTCH3 signaling pathway in glioma. PMID: 29659670
4. Downregulation of SIRT6 expression may promote non-small cell lung cancer malignancy in the Chinese Han population. PMID: 29363378
5. This study provides a comprehensive overview of recent advancements in the molecular signaling pathways controlled by SIRT1 and SIRT6, two post-translational modifiers proven to be valuable tools for mitigating inflammation and oxidative stress in the cardiovascular system. PMID: 28661724
6. Low SIRT6 expression is associated with glioma. PMID: 28677777
7. Low SIRT6 expression is associated with gastric cancer. PMID: 28656307
8. miR378b represses the mRNA expression levels of COL1A1 by interfering with SIRT6 in human dermal fibroblasts. PMID: 28983623
9. SIRT6 is a critical factor in human development, and identifying the first mutation in a chromatin factor behind a human syndrome of perinatal lethality. PMID: 29555651
10. SIRT6 interacts with and promotes phospho-ATF2 binding to the PGC-1α gene promoter, activating its expression. This study reveals a crucial role for SIRT6 in regulating thermogenesis of fat. PMID: 28723567
11. nf-κb levels increase due to SIRT6 silencing in the absence of UV-B. PMID: 29465379
12. p53-dependent SIRT6 expression protects cells from Aβ42-induced DNA damage. PMID: 27156849
13. A strong correlation has been demonstrated between the expression levels of HDAC4 and SIRT6. PMID: 27766571
14. Sirt6 promotes cysteine ubiquitination in the PRE-SET domain of Suv39h1. PMID: 29317652
15. This study not only suggests potential roles of SIRT6 in regulating apoptosis and stress resistance through direct deacetylation of p53 but also provides a lead compound for the development of potent and selective SIRT6 inhibitors. PMID: 29233643
16. In vitro and in vivo studies have shown that gene silencing of SIRT6 suppresses cell proliferation and promotes cellular apoptosis by activating the Bax-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown can increase liver cancer cell sensitivity to the chemotherapy drug doxorubicin. SIRT6 is a significant protumorigenic factor in liver carcinogenesis. PMID: 26861461
17. SIRT6 is upregulated in non-small cell lung cancer and may contribute to promoting migration and invasion through ERK1/2/MMP9 signaling. PMID: 27777384
18. Sirt6 inhibits Notch1 and Notch4 transcription by deacetylating histone H3K9. PMID: 28871079
19. This study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM), suggesting that SIRT6 may play a role in the development of T2DM by altering the expression of genes involved in glucose metabolism through histone modification, rather than its role in DNA repair. PMID: 29197589
20. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
21. SIRT6 overexpression suppresses PI3K signaling. PMID: 28228253
22. Post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is necessary for efficient recruitment of poly(ADP-ribose) polymerase 1 (PARP1) to DNA break sites and for effective repair of double-strand breaks. PMID: 27568560
23. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration. PMID: 28355558
24. Loss- and gain-of-SIRT6 function studies in cultured human endothelial cells (ECs) have shown that SIRT6 attenuates monocyte adhesion to ECs. PMID: 27249230
25. SIRT6 expression decreases during cellular senescence, while forced SIRT6 expression promotes cell proliferation and antagonizes cellular senescence. Furthermore, SIRT6 directly interacts with p27, and SIRT6 significantly rescues senescence induced by p27. PMID: 27794562
26. This research reveals a previously unknown reciprocal influence of SIRT6 and HK2 in regulating autophagy-driven monocyte differentiation. PMID: 28935467
27. This study identifies TRF2 as a novel SIRT6 substrate and demonstrates that acetylation of TRF2 plays a crucial role in regulating TRF2 protein stability, providing a new pathway for modulating its expression level during oncogenesis and damage response. PMID: 27923994
28. SIRT6 overexpression creates a condition where reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with the MZF1/SIRT6 complex, favoring a regulatory state conducive to diminished transcription. PMID: 28478957
29. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma. PMID: 27746184
30. These findings reveal that SUMOylation plays a significant role in regulating Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity. PMID: 26898756
31. HBx increases signs of DNA damage, such as the accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which are reversed by overexpression of PARP1 and/or Sirt6. The physical interaction of HBx and PARP1 accelerates DNA damage by inhibiting the recruitment of the DNA repair complex to damaged DNA sites, potentially leading to the onset of hepatocarcinogenesis. PMID: 27041572
32. Data suggest that, in macrophages, SIRT6 plays a role in preventing atherosclerosis by reducing foam cell formation through an autophagy-dependent pathway involving regulation of the expression of ATG5, LC3B, LAMP1, ABCA1, ABCG1, and MIRN33. (ATG5 = autophagy-related protein 5; LC3B = microtubule-associated protein 1 light chain 3 beta; LAMP1 = lysosomal-associated membrane protein 1; ABCA1/ABCG1 = ATP-binding cassette transporters 1/8). PMID: 28296196
33. These findings reveal a previously unknown role for nasal mucosa steady-state conditions in controlling Sirt6 activity and provide evidence for a relationship between HMGB1 and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), suggesting promising benefits of glycyrrhetinic acid for CRSwNP patients. PMID: 28685526
34. In obese patients, the expression of Sirt6 is reduced. PMID: 28250020
35. SIRT6 is a positive regulator of aldose reductase expression in U937 and HeLa cells under osmotic stress. PMID: 27536992
36. These results suggest that SIRT6 enhances cell aggressiveness in PTC via the BRAF/ERK/Mcl1 pathway, and thus may be a promising target in the treatment of the disease. PMID: 28393212
37. Our studies provide insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and offer evidence supporting sirtuin 6-based personalized therapies for esophageal carcinoma cell patients. PMID: 28653878
38. SIRT6 acts as a tumor promoter by preventing DNA damage and cellular senescence in hepatocellular carcinoma. PMID: 27824900
39. SIRT6 promotes deacetylation of a new substrate, residue K18 of histone H3 (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts. PMID: 27043296
40. Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70) in sirtuin 6 protein (SIRT6)-depleted cells disrupts its interaction with Bax apoptosis regulator protein (Bax), ultimately resulting in Bax mitochondrial translocalization. PMID: 28238784
41. Taken together, these data demonstrated that astragaloside IV sensitized tumor cells to gefitinib via regulation of SIRT6, suggesting that astragaloside IV may serve as a potential therapeutic approach for lung cancer. PMID: 28443459
42. SIRT6 prevents matrix degradation of nucleus pulposus via the NF-κB signaling pathway in intervertebral disc degeneration. SIRT6 physically interacts with nuclear factor-κB (NF-κB). PMID: 28215636
43. The single nucleotide polymorphism rs117385980 (C;T) in sirtuin 6, located 23 bases downstream of the exon 2 exon/intron border, was found in heterozygous form in 1/43 longer-living healthy men (Minor allele frequency (MAF) 0,0116) and in 9/92 controls. PMID: 28399814
44. In the model of CIA, forced expression of SIRT6 ameliorated disease progression, osteoblastic synthesis of Cyr61, and macrophage recruitment. More importantly, expression of LDHA and oxidative lesions were decreased in osteoblasts of SIRT6-treated joints. Our findings suggest that SIRT6 suppresses inflammatory response in osteoblasts through modulation of glucose metabolism and redox homeostasis. PMID: 27534902
45. The data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase activity to SIRT6's various functions. PMID: 27322069
46. This study shows that, through the antiglycolytic activity of SIRT6, autophagy is suppressed, which is beneficial to nasal polyp formation. PMID: 26803106
47. The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls. PMID: 26886147
48. We examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR-21 and subsequently suppressed TGF-β2 expression in a targeted manner. PMID: 26987016
49. SIRT6 induced autophagy through attenuation of AKT signaling, and treatment with the autophagy inhibitor 3-MA or knockdown of autophagy-related protein Atg5 rescued H2O2-induced neuronal injury. PMID: 26983852
50. SIRT6 is an important pancreatic ductal adenocarcinoma tumor suppressor. PMID: 27180906

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HGNC: 14934

OMIM: 606211

KEGG: hsa:51548

STRING: 9606.ENSP00000337332

UniGene: Hs.423756