SLC27A4 Antibody
Shipped with Ice Packs 
In Stock 
Description
SLC27A4 Protein Overview
-
Function: SLC27A4 (FATP4) mediates long-chain fatty acid transport and acyl-CoA ligase activity, critical for fatty acid uptake and metabolism .
-
Expression: High levels in small intestinal enterocytes, skin, and blood-brain barrier .
-
Disease Link:
Antibody Validation Data
-
Western Blot:
-
Immunohistochemistry:
-
Flow Cytometry:
Research Applications
-
Fatty Acid Transport Studies:
-
Developmental Biology:
-
Neurological Disorders:
Gene and Protein Details
Key Experimental Considerations
Product Specs
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Lead Time
Typically, we can ship the products within 1-3 business days of receiving your order. Delivery time may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery times.
Synonyms
SLC27A4; ACSVL4; FATP4; Long-chain fatty acid transport protein 4; FATP-4; Fatty acid transport protein 4; Arachidonate--CoA ligase; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4; ACSVL4
Target Names
Uniprot No.
Target Background
Function
SLC27A4, also known as Fatty Acid Transport Protein 4 (FATP4), is a crucial protein involved in the transport of long-chain fatty acids (LCFAs) across the plasma membrane. It possesses acyl-CoA ligase activity for both long-chain and very-long-chain fatty acids (VLCFAs). FATP4 is considered the primary fatty acid transporter in small intestinal enterocytes, playing a vital role in the formation of the epidermal barrier. It is essential for fat absorption during early embryogenesis and likely participates in fatty acid transport across the blood barrier. Additionally, FATP4 indirectly inhibits RPE65 through substrate competition and the production of VLCFA derivatives like lignoceroyl-CoA, preventing light-induced degeneration of rods and cones in the eye.
Gene References Into Functions
- Mutations in the SLC27A4 gene are associated with ichthyosis prematurity syndrome in premature infants. PMID: 26341232
- Further research has expanded the understanding of SLC27A4 mutations, identifying three novel pathogenic mutations in two families. PMID: 27168232
- Studies suggest that the SLC27A4/ATG4B complex may contribute to the occurrence of autophagy in human cancer cells, potentially leading to new avenues for autophagy-targeting drug development and clinical applications. PMID: 26662804
- Research has found no association between placental SLC27A4 expression and maternal body mass index. PMID: 27016784
- Resequencing of the SLC27A3 and SLC27A4 genes in autism spectrum disorders (ASD) patients and control samples has revealed a high degree of polymorphism with multiple rare variants. PMID: 26548558
- A study reported two siblings with ichthyosis prematurity syndrome carrying a recurrent homozygous mutation (c.1430T>A) leading to a p.Val477Asp substitution in FATP4. PMID: 24889544
- The cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, while intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly through metabolic trapping. PMID: 24503477
- This review explores the clinical implications of defects in fatty acid transporters and relevant animal models, including FATP4 animal models and ichthyosis prematurity syndrome, a congenital ichthyosis caused by FATP4 deficiency. PMID: 24120574
- FATP4, ichthyin, and TGM1 interact in lipid processing crucial for maintaining the epidermal barrier function. PMID: 23290633
- FATP4 plays critical roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum. PMID: 23271751
- FATP1 and FATP4 proteins have distinct functional roles in handling long-chain fatty acids in skeletal muscle. PMID: 22235293
- While hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID: 22028793
- A mutation in FATP4 was identified in a patient with self-healing congenital verruciform hyperkeratosis. PMID: 20815031
- Research suggests that FATP4 could be a candidate gene for the insulin resistance syndrome. PMID: 14715877
- Analysis revealed that FATP4 expression was significantly up-regulated in acquired obesity. PMID: 15168018
- Data indicate that endogenous FATP4 does not primarily function to translocate fatty acids across the plasma membrane but rather acts as a very long-chain acyl-CoA synthetase. PMID: 17901542
- Mutations in the FATP4 gene are known to cause ichthyosis prematurity syndrome. PMID: 19631310
Database Links
Involvement In Disease
Ichthyosis prematurity syndrome (IPS)
Protein Families
ATP-dependent AMP-binding enzyme family
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tiss
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
