SLC38A1 Antibody
Description
Introduction to SLC38A1 Antibody
The SLC38A1 antibody is a specific immunoglobulin designed to detect the SLC38A1 protein, a sodium-coupled neutral amino acid transporter critical for glutamine uptake in neurons and cancer cells. This antibody enables researchers to study SLC38A1’s role in cellular metabolism, neurological function, and oncology through techniques like Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) .
Antibody Characteristics
Applications in Research
The SLC38A1 antibody is instrumental in:
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Cancer Studies: Detecting SLC38A1 overexpression in melanoma, hepatocellular carcinoma, and breast cancer, correlating with tumor progression and poor prognosis .
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Neurological Research: Investigating SLC38A1’s role in glutamine-glutamate cycling, dendritic growth, and neurotrophic factor signaling .
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Therapeutic Studies: Evaluating SLC38A1 inhibition effects on tumor growth and neuronal dysfunction .
Role in Cancer
SLC38A1 is upregulated in aggressive cancers, facilitating glutamine uptake to sustain tumor growth. Studies using the antibody revealed:
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Melanoma: Increased SLC38A1 expression in melanoma tissues vs. healthy skin, linked to enhanced proliferation .
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Hepatocellular Carcinoma: High SLC38A1 levels correlate with poor prognosis and reduced immune infiltration .
Neurological Functions
The antibody has clarified SLC38A1’s involvement in:
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Glutamine Transport: Mediating glutamine uptake in neurons, critical for neurotransmitter synthesis .
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Brain Development: Regulating dendritic branching via neurotrophic factors like BDNF .
Therapeutic Implications
Inhibition of SLC38A1 reduces melanoma cell migration and induces senescence . Additionally, its dysregulation in ischemic brain injury highlights potential neuroprotective targets .
Product Specs
Target Background
- Elevated SNAT1 expression is associated with increased cell migration in breast neoplasms. PMID: 27048259
- This study demonstrates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, providing a new perspective on the role and mechanism of insulin-induced glycolysis. PMID: 27613819
- Research findings indicate that SLC38A1 is upregulated in colorectal cancer cells (CRC) and significantly associated with tumor invasion and advanced disease stage. Its overexpression enhances the growth and migration of HCT116 cells, providing evidence that activation of SLC38A1 may play a crucial role in CRC development and progression. PMID: 28224429
- The SLC38A1 protein was either very low or undetectable in healthy gastric mucosa, whereas strong staining of the SLC38A1 protein was observed in the cytoplasm of more than half of gastric cancer samples. SLC38A1 knockdown decreased tumor cell proliferation and migration, suggesting its involvement in gastric cancer development. PMID: 24712400
- The interplay between Akt signaling and SNAT1 might play a critical role in the development and progression of breast cancer. PMID: 23848995
- Increased expression of ATA1 is frequently observed in human hilar cholangiocarcinoma and significantly correlated with the progression of cholangiocarcinoma, highlighting the importance of ATA1 in cancer development and progression. PMID: 20605601
- The results of this study demonstrate that RAB2A and SLC38A1 are associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. PMID: 20308991
- Findings suggest that slc38a1 may play a role in the mechanisms underlying the determination of cellular viability in astrocytes through modulation of intracellular ROS generation. PMID: 21219957
- SNAT1 is a key contributor to system A activity at term. PMID: 20599747
- These data demonstrate the physiological importance of ATA1 in hepatocarcinogenesis. PMID: 17549407
- This study reports SNAT1 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
- A possible association between low expression of SNAT1 and suicidal behavior is suggested. PMID: 19442705
