SLC38A9 Antibody, HRP conjugated

SLC38A9 is a lysosomal amino acid transporter crucial for activating mTORC1 in response to amino acid levels. It functions as an amino acid sensor, interacting with the Rag GTPases and Ragulator complexes. These complexes are involved in amino acid sensing and the activation of mTORC1, a signaling complex that promotes cell growth in response to growth factors, energy levels, and amino acids. Upon amino acid activation, the Ragulator and Rag GTPases act as a scaffold, recruiting mTORC1 to lysosomes for activation. SLC38A9 transports amino acids with low capacity and specificity, exhibiting a slight preference for polar amino acids. It acts as an arginine sensor; arginine binding enhances the efficient transport of leucine, tyrosine, and phenylalanine, essential for utilizing these amino acids after lysosomal protein degradation.

The following studies highlight the role of SLC38A9:

1. Ragulator and SLC38A9 collaborate with Rag GTPases to activate the mTORC1 pathway under nutrient-rich conditions. (PMID: 30181260)
2. SLC38A9 is an arginine sensor for the mTORC1 pathway, playing a central role in amino acid homeostasis. It regulates the lysosomal transport of essential amino acids, including leucine, which is sensed by cytosolic Sestrin proteins. (PMID: 29053970)
3. SLC38A9 controls mTORC1 activity by binding to the Rag-Ragulator complex at the lysosome in the presence of amino acids. (PMID: 25963655)
4. SLC38A9 is a critical component of the amino acid sensing machinery regulating mTOR activation. (PMID: 25561175)
5. SLC38A9 functions upstream of Rag GTPases and is a potential arginine sensor for the mTORC1 pathway. (PMID: 25567906)
6. Single nucleotide polymorphisms (SNPs) in SLC38A9 correlate with 6-thioguanine nucleotide blood concentrations in inflammatory bowel disease patients. (PMID: 24762746)

HGNC: 26907

OMIM: 616203

KEGG: hsa:153129

STRING: 9606.ENSP00000316596

UniGene: Hs.742101