SLC9A8 Antibody
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In Stock 
Product Specs
Buffer
PBS containing 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze-thaw cycles.
Lead Time
Generally, we can ship products within 1-3 business days after receiving your order. Delivery times may vary based on the purchase method or location. Please consult your local distributors for specific delivery timelines.
Synonyms
Na(+)/H(+) exchanger 8 antibody; NHE 8 antibody; NHE-8 antibody; NHE8 antibody; SL9A8_HUMAN antibody; Slc9a8 antibody; Sodium/ hydrogen exchanger 8 antibody; Sodium/hydrogen exchanger 8 antibody; solute carrier family 9 (sodium/hydrogen exchanger); member 8 antibody; Solute carrier family 9 member 8 antibody
Target Names
SLC9A8
Uniprot No.
Target Background
Function
SLC9A8, also known as NHE8, is a protein that plays a crucial role in maintaining cellular pH balance. This protein functions as a sodium/hydrogen exchanger, actively transporting protons out of the cell to counter the accumulation of acids produced during metabolic processes or due to adverse environmental conditions. NHE8 is also involved in signal transduction pathways, demonstrating its multifaceted role in cellular physiology.
Gene References Into Functions
- Studies have revealed a critical function of NHE8 in acrosome biogenesis. A loss of function in this sodium/hydrogen exchanger may contribute to certain cases of human globozoospermia. PMID: 28476888
- NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates its expression through a transcriptional mechanism. PMID: 26564720
- Exonic mutations in NHE8 have been found not to be the cause of congenital sodium diarrhea. PMID: 21666503
- Research suggests that NHE8's ion exchange activity is essential for maintaining endosome morphology. PMID: 20719963
- Epidermal growth factor (EGF) inhibits intestinal NHE8 gene expression by suppressing its basal transcription. PMID: 20375273
- NHE8 is expressed throughout the gastrointestinal tract and functions as a Na+/H+ exchanger with distinct kinetic characteristics compared to other apically expressed NHE isoforms. PMID: 18209477
- Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity. PMID: 19109523
Database Links
Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity
Ubiquitous. Strongly expressed in skeletal muscle and kidney.
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