SNRPD1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receiving them. Delivery times may vary depending on the purchasing method and location. For specific delivery times, please consult your local distributors.
Synonyms
AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody
Target Names
SNRPD1
Uniprot No.
Target Background
Function
SNRPD1 antibody plays a crucial role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs). These snRNPs are the building blocks of the spliceosome. SNRPD1 is a component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. It also plays a role in the minor U12 spliceosome. SNRPD1 may function as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
Gene References Into Functions
- Research indicates that elevated cerebrospinal fluid anti-Sm antibodies, caused by transudation from systemic circulation due to a compromised blood-brain barrier (BBB), play a significant role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
- The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1) significantly reduces SMN-coilin interaction and hinders Cajal body assembly. PMID: 24413165
- Overexpression of SNRPD1 has been linked to highly aggressive breast cancers. PMID: 23358685
Database Links
Protein Families
SnRNP core protein family
Subcellular Location
Cytoplasm, cytosol. Nucleus.
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