MSD1 Antibody
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Description
Microtubule Anchoring and Centrosome Integrity
MSD1 ensures microtubules are anchored to the centrosome, maintaining cytoskeletal architecture. Depletion of MSD1 disrupts microtubule networks, leading to disorganized spindle orientation .
Mitotic Spindle Regulation
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Spindle Orientation: MSD1 deficiency causes tilted spindles (>20° deviation in 60% of cells) and shortened spindle length .
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Chromosome Alignment: Abnormalities in chromosome positioning observed in siRNA knockdown models .
Ciliogenesis
MSD1 is essential for primary cilia formation. In RPE-1 cells, MSD1 depletion reduced cilia occurrence by 70% and shortened cilia length by 50% .
Interaction Partners
| Partner Protein | Interaction Role | Functional Outcome |
|---|---|---|
| γ-tubulin | Binds via C-terminal domain | Microtubule nucleation and anchoring |
| PCM1 | Associates with N-terminal domain | Centriolar satellite localization |
| Centrosomal proteins | Co-localization | Maintains centrosome structure |
siRNA Knockdown Effects
| Phenotype | Severity (vs. Control) |
|---|---|
| Disorganized microtubules | 85% of cells |
| Tilted mitotic spindles | 60% of cells |
| Impaired cilia formation | 70% reduction |
Applications of MSD1 Antibody in Research
MSD1 antibodies are used in:
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
MSD1 antibody; MEE3 antibody; SODA antibody; At3g10920 antibody; F9F8.26 antibody; Superoxide dismutase [Mn] 1 antibody; mitochondrial antibody; EC 1.15.1.1 antibody; Protein MANGANESE SUPEROXIDE DISMUTASE 1 antibody; AtMSD1 antibody; Protein MATERNAL EFFECT EMBRYO ARREST 33 antibody
Target Names
MSD1
Uniprot No.
Target Background
Function
MSD1 Antibody targets manganese superoxide dismutase (MSD1), a crucial enzyme in cellular defense against oxidative stress. MSD1 effectively neutralizes superoxide anion radicals, highly reactive molecules generated within cells, which can damage biological systems.
Gene References Into Functions
- Peroxynitrite has been shown to inhibit mitochondrial manganese superoxide dismutase (SOD1; MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), although other SODs remained unaffected. MSD1 was significantly inhibited by up to 90%, while CSD3 and FSD3 exhibited a maximum inhibition of 30%. PMID: 25428993
- Manganese superoxide dismutase from Arabidopsis has been successfully expressed, purified, and crystallized. PMID: 24817734
- Research suggests that Mn-superoxide dismutase MSD1 activity is essential for maintaining the proper localization of reactive oxygen species (ROS) and plays a significant role in embryo sac patterning. PMID: 23653473
- Reduced MnSOD levels have been linked to disruptions in mitochondrial redox balance and subsequent negative impacts on plant growth. PMID: 18337490
Database Links
Protein Families
Iron/manganese superoxide dismutase family
Subcellular Location
Mitochondrion matrix.
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