Spo0F is a key component in the phosphorelay signaling pathway that initiates sporulation in bacteria. Its phosphorylation during this process plays a crucial role in regulating the initiation of sporulation.
Gene References Into Functions
The crystal structure of the manganese derivative of Spo0F has been determined at a resolution of 2.25 Å. In its apo form, the active site cation cavity is only partially formed and becomes fully completed upon metal coordination. PMID: 15039551
Phosphorylation of Spo0F leads to a reduction in protein flexibility. Notably, the regions known as the 'anchor' and 'recognition' regions exhibit lower mobility compared to the apo-conformation. PMID: 19004019