spd-5 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
spd-5 antibody; F56A3.4 antibody; Spindle-defective protein 5 antibody
Target Names
spd-5
Uniprot No.
Target Background
Function
SPD-5 plays a pivotal role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. It is essential for the centrosomal localization of air-1 and zyg-9 proteins. While its role is crucial in early embryogenesis, it is likely not required during later stages of development, including larval development.
Gene References Into Functions
- SPD-5 facilitates the recruitment of the scaffold component SPD-5 throughout the pericentriolar material (PCM). This indicates that the incorporation of additional PCM subunits is not restricted to specific nucleation sites near centrioles. PMID: 26241136
Database Links
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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