SPEAR3 Antibody
Description
SPEAR3 as a Particle Accelerator
The Stanford Synchrotron Radiation Lightsource (SSRL) operates a storage ring called SPEAR3 (Stanford Positron Electron Asymmetric Ring 3), which is used for X-ray spectroscopy and beamline experiments. For example:
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Applications: SPEAR3 supports biophysical studies, such as iron characterization in mitochondria ([Table 1, Search Result 9] ).
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Technical specifications: Runs at 3.0 GeV and 80–100 mA beam current.
SPEAR as a DNA Nanotechnology Platform
Harvard-developed SPEAR (Successive Proximity Extension Amplification Reaction) is a reagent-based platform for ultrasensitive protein detection, including neutralizing antibody assays for SARS-CoV-2 ([Search Result 4] ). Key features:
| Feature | Description |
|---|---|
| Sensitivity | Detects proteins/antibodies in sample volumes as low as 1 µL. |
| Workflow | Wash-free, proximity-based detection with qPCR readout. |
| Applications | Neutralizing antibody (NAb) quantification for COVID-19 research and diagnostics. |
Potential Misinterpretations
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Antibody nomenclature: Standard antibody naming conventions (e.g., "SPEAR3") were not identified in peer-reviewed publications.
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IgG3 antibodies: While not "SPEAR3," engineered IgG3 antibodies show enhanced viral neutralization due to structural features like elongated hinge regions ([Search Results 3, 7] ).
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- TIE1 (At4g28840) plays a crucial role in regulating leaf size and morphology. It achieves this by inhibiting the activity of TCP transcription factors through the recruitment of TOPLESS/TOPLESS-RELATED corepressors. These components form a tertiary complex during the early stages of leaf development. PMID: 23444332
