SPH27 Antibody

SC27 Monoclonal Antibody: Broad-Spectrum COVID-19 Neutralization

SC27 is a monoclonal antibody developed to combat SARS-CoV-2 and related coronaviruses. Key features include:

Research Highlights:

• SC27 binds two distinct epitopes: the ACE2 receptor-binding domain and a conserved cryptic region on the spike protein’s underside, minimizing viral escape .

• Preclinical studies show efficacy against Omicron subvariants and animal coronaviruses (e.g., WIV1, RaTG13) .

• Unlike earlier monoclonal antibodies (e.g., REGEN-COV), SC27 remains effective against evolving variants due to its dual targeting .

HSP27 Antibodies: Roles in Disease and Diagnostics

Heat shock protein 27 (HSP27) is a molecular chaperone involved in cellular stress response. Antibodies targeting HSP27 are linked to autoimmune and oncological conditions:

Key Applications and Findings

Mechanistic Insights:

• Autoimmune Action: Anti-HSP27 antibodies internalize via endocytosis, destabilizing actin and triggering apoptosis .

• Therapeutic Target: Phosphorylation at Ser78/Ser82 modulates HSP27’s anti-apoptotic function; antibodies detecting these sites are critical for research (e.g., MAB23141, #2401) .

Comparative Analysis: SC27 vs. HSP27 Antibodies

Technical Data: Anti-HSP27 Antibody Performance

ELISA Performance:

• Anti-HSP27 antibodies in pemphigus patients showed 0.40±0.11 AU vs. 0.16±0.14 AU in controls (p<0.001) .

• Ovarian cancer patients exhibited elevated anti-HSP27 levels, particularly in early-stage disease .