SPS3 Antibody
Description
SP3 Antibody (Transcription Factor)
The SP3 antibody (Product ID: 26584-1-AP) targets the SP3 transcription factor, a protein critical for gene regulation.
SPS3 Clinical Trial (Secondary Prevention of Small Subcortical Strokes)
SPS3 refers to a multicenter NIH-sponsored trial (NCT00059306) investigating stroke recurrence prevention. It tested dual antiplatelet therapy (aspirin + clopidogrel) vs. aspirin alone and intensive vs. standard blood pressure control in 3,020 patients with lacunar strokes.
Key Outcomes
| Intervention | Result |
|---|---|
| Dual Antiplatelet Therapy | No reduction in stroke recurrence; increased hemorrhage risk |
| Blood Pressure Target | Systolic <130 mmHg reduced recurrent strokes vs. 130–149 mmHg |
This trial did not involve antibodies but focused on pharmacological and blood pressure interventions .
PS3 Phenotype in Myasthenia Gravis (MG)
A 2024 study identified PS3 as a subgroup of MG patients characterized by:
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High-affinity anti-AChR antibodies inducing potent complement activation.
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Hyperexpanded B-cell clones (10–20% of heavy-chain repertoire).
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Elevated MAC formation (mean difference: 31.4 vs. non-PS3, P < 0.0001) .
Clinical Implications
| Parameter | PS3 vs. Non-PS3 |
|---|---|
| Steroid Dose | Higher time-weighted average (median difference: 3.9 mg/day) |
| Treatment Response | Greater MG-ADL improvement with C5 inhibitors (Δmedian: 4 points) |
PS3 patients showed enhanced response to complement inhibitors (eculizumab/ravulizumab) .
Antibody Engineering: PALM-H3 Model
Though unrelated to "SPS3," the PALM-H3 AI model generates synthetic antibody CDRH3 sequences targeting SARS-CoV-2 variants (e.g., XBB). Key features:
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Pre-trained on 1.2M antibody sequences (UniRef50).
Data Synthesis Table
| Term | Context | Relevance to Antibodies |
|---|---|---|
| SP3 Antibody | Transcription factor research | Direct antibody application |
| SPS3 Trial | Stroke prevention trial | No antibody involvement |
| PS3 Phenotype | Autoimmune disease stratification | Antibody-mediated pathology |
| PALM-H3 | AI-driven antibody design | Novel therapeutic development |
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Phylogenetic analysis has revealed that At2g34630, an Arabidopsis trans-long-chain prenyl diphosphate synthase, clusters with Coq1 orthologs, which are known to play a crucial role in ubiquinone biosynthesis in various eukaryotes. PMID: 21950843
- A newly identified prenyltransferases from Arabidopsis thaliana has been characterized as a trans-type polyprenyl pyrophosphate synthase, responsible for the synthesis of various medium/long-chain products. [AtPPPS] PMID: 21220764
