SPS1 Antibody
Description
SPSB1 Antibody Overview
The SPSB1 antibody (product ID: 12194-1-AP) is a rabbit polyclonal antibody validated for use in ELISA and immunoblotting. Key characteristics include:
This antibody is purified via antigen-affinity chromatography and is available in liquid form. Its application in research remains limited to studies investigating SPSB1’s role in cellular processes, though specific experimental data are not detailed in the provided sources .
Research Findings on SPSB1 Antibody Applications
While direct functional studies of the SPSB1 antibody are absent in the sources, its development aligns with broader trends in antibody research:
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Target-Specific Binding: Polyclonal antibodies like 12194-1-AP are designed to bind multiple epitopes on SPSB1, enhancing sensitivity in assays .
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Cross-Reactivity: The antibody’s validated reactivity with human, mouse, and rat samples highlights its utility in comparative studies .
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Diagnostic Potential: SPSB1’s involvement in signaling pathways (e.g., SOCS box-containing proteins often modulate cytokine signaling) could position this antibody as a tool for studying immune regulation or disease mechanisms .
Comparative Analysis of SPS1-Related Proteins and Antibodies
To contextualize the lack of SPS1 antibody data, we contrast it with SPSB1 and other SPS-related proteins:
Key Insight: SPS1’s role in selenium metabolism and redox homeostasis is well-documented, but its immunological targeting remains unexplored. In contrast, SPSB1 antibodies are available but underutilized in current research.
Challenges and Limitations in SPS1 Antibody Development
The absence of SPS1-specific antibodies in the literature raises several challenges:
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Low Commercial Demand: SPS1’s niche role in selenium biochemistry may limit antibody development compared to high-profile targets like viral proteins (e.g., SARS-CoV-2 RBD in ).
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Technical Complexity: Selenoproteins are challenging to study due to their dependence on selenium, complicating antibody production and validation .
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Nomenclature Confusion: The overlap between SPS1 and SPSB1 in gene symbol databases (e.g., NCBI) risks misattribution of antibody data .
Future Directions for SPS1-Related Antibody Research
To advance SPS1 antibody development, researchers could:
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Leverage Structural Insights: SPS1’s homology to SPS2 could inform epitope selection for antibody engineering.
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Adopt High-Throughput Platforms: Antibody libraries (e.g., phage display in ) could accelerate discovery of SPS1 binders.
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Collaborate Across Disciplines: Partnerships between selenium biochemistry and immunology labs may bridge knowledge gaps.
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Regulation of sucrose-phosphate synthase by BSK8 occurs through activation of a phosphatase, which in turn dephosphorylates sucrose-phosphate synthase, leading to activation of the enzyme. PMID: 24924143
- SPSA1 plays a significant role in photosynthetic sucrose synthesis in Arabidopsis leaves. Decreases in leaf SPS activity result in increased starch synthesis and turnover, along with decreased RuBP regeneration-limited photosynthesis but not Rubisco-limited photosynthesis. PMID: 21309792
