SRPX Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery timelines may vary depending on the purchase method and location. Please consult your local distributor for specific delivery times.
Synonyms
SRPX antibody; ETX1 antibody; Sushi repeat-containing protein SRPX antibody
Target Names
SRPX
Uniprot No.
Target Background
Function
SRPX may be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium, or signal transduction.
Gene References Into Functions
- SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA). Notably, no SRPX1 co-accumulated with Abeta deposits in senile plaques. Additionally, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40. PMID: 28478503
- The SRPX protein contains the P-DUDES structural domain in its C-terminal region. This domain exhibits significant, albeit remote, sequence similarity to thioredoxin-like domains and is predicted to possess an oxidoreductase function. PMID: 209648
- PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G, and SRPX proteins. This interaction occurs at the cytoskeleton and may facilitate PELO's ability to detect and degrade aberrant mRNAs. PMID: 20406461
- An apoptosis-inducing protein localized in the endoplasmic reticulum, which increases the efficiency of apoptosis. PMID: 15021917
- drs mRNA expression is observed in well-differentiated, moderately differentiated, and poorly differentiated lung adenocarcinoma tissues (drs; down-regulated by v-scr). PMID: 12152160
- Down-regulation of drs mRNA is closely correlated with carcinomas that arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene. PMID: 12716466
- Down-regulation of drs mRNA is closely correlated with the development of prostate carcinoma, suggesting a tumor suppressor function of the drs gene in this cancer. PMID: 12874760
- Downregulation of the drs tumor suppressor gene is observed in highly malignant human pulmonary neuroendocrine tumors. PMID: 19424611
- This is the first report demonstrating overexpression of ETX1 in glaucomatous trabecular meshwork. PMID: 19862339
Database Links
Subcellular Location
Cell surface. Note=Possibly surface of photoreceptor cell.
Tissue Specificity
Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain.
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