stim-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
stim-1 antibody; Y55B1BM.1 antibody; Stromal interaction molecule 1 antibody
Target Names
stim-1
Uniprot No.
Target Background
Function
STIM1 is a transmembrane protein that plays a crucial role in mediating store-operated calcium entry (SOCE), a calcium influx triggered by the depletion of intracellular calcium stores. It acts as a calcium sensor, and upon calcium depletion, activates the calcium release-activated calcium (CRAC) channel subunit, Orai-1. This activation is essential for calcium and inositol trisphosphate (IP3)-dependent contractile activity in gonad sheath cells and the spermatheca, playing a vital role in fertility. Importantly, STIM1 does not appear to be involved in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory calcium signaling, or intestinal ER calcium homeostasis.
Gene References Into Functions
- Tyrosine316 is thought to be involved in the auto-inhibitory mechanism of the STIM1 C-terminus in its inactive state. PMID: 23795811
- Functional studies suggest that the inhibitory helix maintains the C-terminus of STIM1 in an inactive state. PMID: 22451904
- This study explores STIM-1 function in a living organism and suggests that store-operated calcium entry is not essential for certain oscillatory calcium signaling processes and the maintenance of calcium levels in the endoplasmic reticulum of *C. elegans*. PMID: 16966474
- This review delves into the role of STIM1 in calcium release activated calcium (CRAC) channel activity within the gonad and intestine of *C. elegans*. PMID: 17376526
Database Links
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Coexpressed with orai-1 in spermatheca, gonad sheath cells and intestine. Also detected in neurons in the head and in the uterine epithelial cells. Heterogeneously expressed in the intestine with strong presence in the anterior and posterior intestine and
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