STIM2 Antibody

1. Co-expression of full-length STIM1 with STIM2 in a 5:1 ratio leads to suppression of sustained agonist-induced Ca²⁺ oscillations and protects cells from Ca²⁺ overload. PMID: 29581306
2. Deletion of Stim2 in NIH 3T3 cells reduced SOCE by more than 90% and eliminated STIM1 translocation to plasma membrane-associated ER membrane junctions. PMID: 29783744
3. While STIM2 is essential for life but not for development, recent findings highlight the complex and intriguing nature of its function, as summarized in this review, providing an update on current knowledge. PMID: 28087881
4. The STIM2 protein plays a significant role in TGF-beta-induced EMT (epithelial-mesenchymal transition), with effects linked to both store-operated and non-store-operated calcium entry. PMID: 28479254
5. Understanding the spatial and temporal regulation of intracellular Ca²⁺ spread by the differential expression of individual SOCE genes, splice variants, heteromeric combinations, and pre- and post-translational modifications remains an ongoing area of investigation. This review focuses on key mechanisms regulating expression, splicing, and targeting of Ca²⁺ release-activated Ca²⁺ (CRAC) channels. PMID: 26911279
6. While STIM1 is a full Orai1 agonist, replacing leucine with another amino acid in this critical residue within STIM2 confers partial agonist properties. This may be crucial for limiting Orai1 activation due to STIM2's enhanced sensitivity to store depletion. PMID: 24492416
7. These results suggest that the splice variant STIM2.1 plays an additional role in fine-tuning Orai1 activation in vivo. PMID: 25896806
8. STIM2.1 cannot activate Orai1 due to splicing within residues of the channel-activating domain (CAD). STIM2.1 exhibits a calcium-dependent dominant-negative function on both STIM1 and STIM2 (STIM2.2). Compared to STIM2.2, the affinity of the STIM2.1 calmodulin binding site within the CAD domain is increased. PMID: 25896806
9. STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting the recruitment of STIM1 to the ER-plasma membrane junctions. PMID: 25587190
10. STIM2beta, while not strongly binding Orai1 on its own, is recruited to Orai1 channels through heterodimer formation with other STIM isoforms. PMID: 26033257
11. Imin channels are regulated by STIM2, TRPC3-containing INS channels are induced by STIM1, and TRPC1-composed Imax channels are activated by both STIM1 and STIM2. PMID: 25533457
12. The higher amplitude of store-operated Ca²⁺ entry was associated with overexpression of Stim2, Orai2-3, and TRPC1, while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1, and TRPC4 proteins were overexpressed in primary myelofibrosis. PMID: 24603752
13. A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺ remodeling and cancer hallmarks in colorectal carcinoma cells. PMID: 25143380
14. STIM2 is highly expressed and controls store-operated Ca²⁺ entry in human melanoma. Silencing STIM2 reduced the invasive and migratory potential of melanoma cells. PMID: 24472175
15. Binding of the lysine-rich domains of STIM1 and STIM2 to phosphatidylinositol 4,5 biphosphate-rich liposomes is dependent on their oligomerization. PMID: 24044355
16. STIM2 is implicated in spatial learning and plays a significant role in ischemic-induced neuronal cell death during brain hypoxia. The absence of STIM2 reduces life expectancy in mice due to sudden death. PMID: 198439
17. STIM2 regulates store-operated Ca²⁺ entry as a sensor of mild reductions in ER calcium levels. PMID: 23359669
18. This review examines the role of STIM2 in store-operated calcium entry and its relevance in cellular physiology. PMID: 22477146
19. Studies indicate that in vertebrates, stromal interaction molecule proteins STIM1 and STIM2 are expressed ubiquitously. PMID: 22914293
20. Polyamines have been shown to regulate intestinal epithelial restitution through TRPC1-mediated Ca²⁺ signaling by altering the STIM1 to STIM2 ratio. Overexpression of ornithine decarboxylase resulted in increased STIM1 but decreased STIM2 expression. PMID: 22592407
21. Stromal interaction molecule 2 is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. PMID: 22125164
22. Stim1 and Stim2 levels were elevated in the brains of chronic epileptic rodents and exhibited strong expression in hippocampal specimens from medial temporal lobe epilepsy patients. PMID: 21906591
23. STIM1 and STIM2 are located in the acidic Ca²⁺ stores and associate with Orai1 upon depletion of these stores in human platelets. PMID: 21321120
24. A new model proposes that two distinct proteins, STIM2 and preSTIM2, regulate the store-dependent and store-independent modes of ORAI1 activation mediated by STIM2. PMID: 21383014
25. Evidence suggests that divergent Ca²⁺- and SAM-dependent stabilization of the EF-SAM fold contributes to the distinct regulatory roles of STIM1 and STIM2 in store-operated Ca²⁺ entry. PMID: 21217057
26. STIM2 is implicated in both store-operated calcium entry and cell proliferation. PMID: 20172609
27. STIM2 is a necessary partner of STIM1 for excitation-contraction coupling. PMID: 20436167
28. STIM proteins act as Ca²⁺ store sensors in the signaling pathway linking Ca²⁺ store depletion to Ca²⁺ influx. PMID: 16005298
29. STIM2 functions as an inhibitor of store-operated channel (SOC) activation and plays a coordinated role with STIM1 in controlling SOC-mediated Ca²⁺ entry signals. PMID: 16860747
30. STIM2 exhibits two modes of activating CRAC channels: a store-operated mode triggered by depletion of ER Ca²⁺ stores via inositol 1,4,5-trisphosphate, and a store-independent activation mediated by cell dialysis. Both modes are regulated by calmodulin. PMID: 17905723
31. This study positions STIM2 as a central component of a feedback module that maintains tight control over basal cytosolic and ER Ca²⁺ concentrations. PMID: 18160041
32. Biophysical investigations reveal a structural stability difference in the EF-SAM region between STIM1 and STIM2, potentially explaining their distinct biological functions. PMID: 18166150
33. Distinct oligomerization dynamics of STIM isoforms have evolved to accommodate their differing roles in Ca²⁺ homeostasis and signaling. PMID: 19019825
34. Findings demonstrate that cellular levels of STIM1 and STIM2, key players in capacitative Ca²⁺ entry, are dependent on presenilins. PMID: 19111578
35. Results provide evidence for a role of STIM1 protein in controlling Ca²⁺ influx in neutrophils, excluding STIM2 involvement in this process. PMID: 19433064
36. Results indicate that substituting the 55-amino-acid STIM2 terminus into STIM1 significantly enhances both Orai1-mediated Ca²⁺ entry and constitutive coupling to activate Orai1 channels. PMID: 19487696
37. Translation initiation occurs from a non-AUG (UUG) start site. PMID: 11463338

HGNC: 19205

OMIM: 610841

KEGG: hsa:57620

STRING: 9606.ENSP00000417569

UniGene: Hs.744950