STK39 (Ab-311) Antibody

1. Genetic variations in STK39, specifically SNP rs1468326, have been linked to hypertension in Tibetan individuals, alongside variations in WNK1 (SNP rs6749447) and a specific WNK1 haplotype (AGACAGGAATCGT). PMID: 28945285
2. A study in the Chinese population found no association between STK39 polymorphisms and Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), or multiple system atrophy. PMID: 29564728
3. Research suggests that the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39. This finding provides insights into the regulation of cellular genes by the transcription factor EBNA3A. PMID: 29367247
4. STK39 has been identified as a tumor oncogene in non-small cell lung cancer, making it a potential biomarker for carcinogenesis. PMID: 27542260
5. Meta-analysis findings suggest that STK39 may not be a gene contributing to hypertension susceptibility. PMID: 27142475
6. A study in a male Chinese Han population revealed a significant association of the STK39 rs3754777 polymorphism with essential hypertension, but not the rs35929607 polymorphism. PMID: 26911228
7. No significant difference in allele and genotype distribution was observed for rs1955337 in STK39 between individuals with Parkinson's disease and controls. PMID: 26914237
8. Single nucleotide polymorphisms in STK39 and WNK1 were associated with hypertension and blood pressure in a multicenter Belgian case-control study. PMID: 27082544
9. Aberrant expression of STK39 mRNA and protein has been observed in individuals with primary hypertension, correlating with blood pressure variations. PMID: 26662444
10. SPAK protein has the potential to upregulate KCNQ1/E1 protein abundance in the cell membrane, potentially playing a role in regulating cell volume, excitability, epithelial transport, and metabolism. PMID: 26584301
11. Research indicates that the CCT domain is critical for controlling SPAK activity and blood pressure. PMID: 25994507
12. Findings suggest that STK39 mRNA expression is increased in rs3754777 knockin cell lines. PMID: 26416847
13. The STK39 rs1955337 TT genotype has been identified as a risk factor for Parkinson's disease in Taiwanese individuals of Han Chinese descent. PMID: 26469904
14. Studies suggest a potential interactive role of multiple STK39 gene polymorphisms in the development of hypertension among northeastern Han Chinese. PMID: 24873805
15. In Chinese children, no association was found between genetic variations in CSK, MTHFR, CYP17A1, STK39, and FGF5 and blood pressure or hypertension risk. PMID: 23759979
16. Short forms of SPAK protein in the kidney are generated through proteolytic cleavage mediated by aspartyl aminopeptidase (Dnpep). PMID: 25164821
17. A study in the Chinese Han population confirmed the association of the locus rs11711441 near STK39 with sporadic Parkinson disease. PMID: 24631562
18. Genetic variations in STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence Parkinson's disease risk. PMID: 24312176
19. SPAK isoforms can inhibit both NKCC1 and NKCC2 activity (cation cotransporters), which may be significant in renal physiology. PMID: 24133122
20. A significant association was observed between the STK39 genetic variant rs6749447 and hypertension in a Finnish cohort. PMID: 23235358
21. The essential hypertension risk conferred by the STK39 rs35929607 polymorphism (A/G) differed from previous observations in a European population. PMID: 23894895
22. A study found no evidence to support an association between STK39 and hypertension in the Chinese population. PMID: 23151749
23. Meta-analysis confirms a significant association between STK39 polymorphisms and hypertension susceptibility in both European and East Asian populations. PMID: 23527223
24. SPAK and OSR1, often coexpressed in cells, can form functional heterodimers. PMID: 23034389
25. STK39 has been identified as an independent risk factor for hypertension in men, and its intragenic single nucleotide polymorphisms can interact and play a role in regulating blood pressure. PMID: 20889219
26. Research suggests no significant association between any of the core autism symptom domains or the four additional previously identified familial features and the rs1807984 SNP on the STK39 gene. PMID: 21442361
27. SPAK increases intestinal epithelial permeability. Both SPAK-transfected Caco2-cells and SPAK transgenic mice exhibit a loss of intestinal barrier function and homeostasis in inflammatory bowel disease. PMID: 21705622
28. Serine/threonine kinase 39 is a candidate gene for primary hypertension, particularly in women. PMID: 21178783
29. The phosphorylation-induced activation of NKCC1 by osmotic shrinkage does not involve AMP-activated protein kinase and is likely due to STE20/SPS1-related proline/alanine-rich kinase activation. PMID: 20442269
30. STK39 expression is influenced by polymorphisms acting in cis, and the typed SNPs are associated with allelic expression of this gene. However, there is no evidence of an association with blood pressure in a British Caucasian cohort. PMID: 20003416
31. STK39 plays roles in the phosphorylation and activation of the Na-K-Cl cotransporter (NKCC1). PMID: 12740379
32. Downregulation of SPAK by TNF-related apoptosis-inducing ligand (TRAIL) is a crucial event that enhances its apoptotic effects. PMID: 16950202
33. Evidence suggests linkage and association between autism and loci within the 2q24-q33 region, including at STK39. PMID: 18348195
34. PKCdelta acts upstream of SPAK to increase the activity of NKCC1 during hyperosmotic stress. PMID: 18550547
35. During inflammatory conditions, TNF-alpha is a key regulator of SPAK expression. PMID: 18787102
36. Variants in STK39 may influence blood pressure by increasing STK39 expression, consequently altering renal Na(+) excretion. PMID: 19114657
37. Data suggest that SPAK, whose transcription is regulated by hyperosmolarity, plays a significant role in epithelial barrier function. PMID: 19343169
38. Brain WNK3 acts in tandem with SPAK, while renal WNK3 seems to upregulate NCCT through a SPAK-independent pathway. PMID: 19470686
39. SPAK loss in B-cell lymphomas promotes increased cell survival with DNA damage, providing a potential mechanism for increased resistance to genotoxic stress in cancer. PMID: 19717643

Show More

Hide All

HGNC: 17717

OMIM: 607648

KEGG: hsa:27347

STRING: 9606.ENSP00000348278

UniGene: Hs.276271