strm-1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
strm-1 antibody; H14E04.1 antibody; Sterol 4-C-methyltransferase strm-1 antibody; EC 2.1.1.- antibody
Target Names
strm-1
Uniprot No.
Target Background
Function
STRM-1 is a methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-methionine to the C-4 position of A-ring sterols, such as lathosterone (5alpha-cholest-7-en-3-one). This methylation reaction renders these sterols unsuitable as precursors for the synthesis of dafachronic acids. Dafachronic acids are hormones that act as ligands for the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and promoting reproductive growth. By reducing the biosynthesis of dafachronic acids, STRM-1 can effectively regulate dauer larva formation.
Gene References Into Functions
- A methyltransferase, STRM-1, was identified that modulates dafachronic acid levels and consequently influences dauer formation. PMID: 19531354
Database Links
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Erg6/SMT family
Tissue Specificity
Expressed in the pharynx and hypodermal syncytium.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
