SULT2B1 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery time estimates.
Synonyms
Alcohol sulfotransferase antibody; EC 2.8.2.2 antibody; HSST2 antibody; Hydroxysteroid sulfotransferase 2 antibody; ST2B1 antibody; ST2B1_HUMAN antibody; Sulfotransferase 2B1 antibody; Sulfotransferase family cytosolic 2B member 1 antibody; SULT2B1 antibody; SULT2B1a antibody; SULT2B1b antibody
Target Names
SULT2B1
Uniprot No.
Target Background
Function
SULT2B1 is a sulfotransferase enzyme that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as a sulfonate donor to catalyze sulfate conjugation. It plays a crucial role in the sulfation of cholesterol and is responsible for the sulfation of the 3beta-hydroxyl groups of steroids, including pregnenolone and dehydroepiandrosterone (DHEA). SULT2B1 exhibits a strong preference for cholesterol sulfation, but also demonstrates significant activity towards pregnenolone and DHEA. This enzyme is involved in epidermal cholesterol metabolism and the regulation of epidermal proliferation and differentiation. Notably, SULT2B1 preferentially sulfonates pregnenolone over cholesterol.
Gene References Into Functions
- Research findings have clearly demonstrated the impact of genetic polymorphisms on the cholesterol-sulfating activity of SULT2B1b allozymes, highlighting potential differences in cholesterol metabolism among individuals with varying SULT2B1b genotypes. PMID: 29701841
- Mutations in the SULT2B1 gene lead to an autosomal-recessive congenital ichthyosis phenotype, characterized by increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism. PMID: 28575648
- Given that 1'-hydroxyestragole readily induces DNA damage in B-13/H cells, these findings suggest that cholangiocarcinomas developed in rats consuming estragole may be partially dependent on SULT2B1 activation of the 1'-hydroxyestragole metabolite. PMID: 26739637
- Overexpression of SULT2B1b serves as an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. PMID: 26121319
- This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers collectively associated with an elevated risk of prostate cancer progression. PMID: 24682418
- The SULT2B1 isoforms possess a unique 50 amino acid carboxy-terminal sequence that is absent in other human SULT isoforms (review). PMID: 24020383
- Evidence suggests that cholesterol sulfate (CS) and SULT2B1b inhibit gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
- SULT2B1 expression is induced by calcitriol activated vitamin D receptor in human prostate cancer cells. PMID: 23579488
- SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, potentially contributing to the progression of HCC. PMID: 23593328
- In HT29 cells, SULT2B1 expression was enhanced by probiotic fermentation supernatants without aleurone. PMID: 21840698
- The Ca(2+)-bound form of SULT2B1 may be physiologically relevant for stressed cells with an elevated free calcium level. PMID: 20329768
- The expression of SULT2B1b mRNA in endometrial stromal cells is induced by progesterone, while in endometrial epithelial cells it is induced by relaxin via the cAMP pathway. PMID: 19243756
- Alternative splicing of SULT2B1 results in the production of either cholesterol sulfotransferase or pregnenolone sulfotransferase. PMID: 12145317
- The crystal structure of hydroxysteroid sulfotransferases SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate and acceptor substrate pregnenolone revealed distinct catalytic binding orientations. PMID: 12923182
- The presence of the enzyme SULT2B1b, which sulfonates cholesterol, has been documented in human platelets. Furthermore, the influence of plasma lipoproteins on the expression and activity of this enzyme has been investigated. PMID: 14676143
- The differential subcellular localization of SULT2B1b in prostate and placenta suggests that this enzyme may be subject to different regulatory mechanisms and potentially exhibit distinct physiological functions in these hormonally responsive human tissues. PMID: 14741047
- The confinement of SULT2B1b to the granular layer of the epidermis, coinciding with the region of highest cholesterol sulfate content, suggests that the physiological action of cholesterol sulfate likely occurs within this area of the living epidermis. PMID: 15140224
- Immunohistochemical localization of SULT2B1b in human tissues revealed expression in the cytoplasm of ciliated columnar or cuboidal epithelial cells in terminal bronchia. PMID: 15878639
- Among the five Sp1 elements identified in SULT2B1, two exhibited regulatory activity utilizing immortalized human keratinocytes. PMID: 15953604
- SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating the injurious effects of these compounds in vivo. PMID: 17347498
- Results indicate that SULT2B1 polymorphisms impact enzyme functions. PMID: 17496163
- SULT2B1 is involved in regulating prostate cell responsiveness to dehydroepiandrosterone and delta5-androstenediol. PMID: 17626250
- Data reveal that SULT2B1b is localized within the cytosol and nuclei of both cancerous and normal breast tissue. Notably, African Americans exhibited significantly higher levels of SULT2B1b in the nuclei of epithelial cells of normal breast tissue compared to Caucasians. PMID: 18586095
Database Links
Involvement In Disease
Ichthyosis, congenital, autosomal recessive 14 (ARCI14)
Protein Families
Sulfotransferase 1 family
Subcellular Location
Cytoplasm, cytosol. Microsome. Nucleus.
Tissue Specificity
Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
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