SULT4A1 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days after receiving it. Delivery time may vary depending on the purchase method and location. Please consult your local distributors for specific delivery timeframes.
Synonyms
BR STL 1 antibody; Brain sulfotransferase like protein antibody; Brain sulfotransferase-like protein antibody; Brain sulphotransferase like antibody; BRSTL1 antibody; DJ388M5.3 antibody; hBR STL 1 antibody; hBR STL antibody; hBR-STL antibody; hBR-STL-1 antibody; MGC40032 antibody; Nervous system cytosolic sulfotransferase antibody; Nervous system sulfotransferase antibody; NST antibody; OTTHUMP00000028875 antibody; ST4A1 antibody; ST4A1_HUMAN antibody; Sulfotransferase 4A1 antibody; Sulfotransferase family 4A member 1 antibody; Sulfotransferase related protein antibody; SULT4A1 antibody; SULTX3 antibody
Target Names
SULT4A1
Uniprot No.
Target Background
Function
SULT4A1 is an atypical member of the sulfotransferase family. It exhibits very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and displays minimal catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. This suggests a potential role in the metabolism of drugs and neurotransmitters within the central nervous system.
Gene References Into Functions
- Research indicates that SULT4A1 is widely expressed across various human tissues. However, it primarily exists as a splice variant that produces a rapidly degraded protein. Dimerization of the protein offers protection against degradation. PMID: 24988429
- A study analyzing three psychiatric disorders (n=2815 patients) revealed no consistent association between SULT4A1-1 status and the efficacy of atypical antipsychotic medications. PMID: 25340730
- This research provides further evidence supporting the observation that individuals with SULT4A1-1-positive status may experience enhanced responses to olanzapine treatment compared to those with SULT4A1-1-negative status. PMID: 24956247
- Determining the SULT4A1-1 haplotype status could potentially be useful for identifying patients who are more likely to exhibit an improved response to long-term olanzapine treatment. PMID: 21521020
- This study provides the first immunohistochemical localization of SULT4A1 within the human brain. PMID: 14623933
- SULT4A1 has been identified as a candidate gene for susceptibility to schizophrenia. PMID: 16152568
- These findings provide the first evidence of how genetic variations in Sult4A1 may be linked to clinical symptoms and cognitive function in individuals with schizophrenia. PMID: 18823757
- The lack of polymorphisms within the coding region of the SULT4A1 gene is highly unusual and, coupled with its high conservation across species, suggests a crucial in vivo function for SULT4A1. PMID: 19125109
- Cytosolic SULT4A1 interacts with PIN1. PMID: 19439498
Database Links
Protein Families
Sulfotransferase 1 family
Subcellular Location
Cytoplasm.
Tissue Specificity
Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas. Highly expressed in
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