SYT11 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze-thaw cycles.
Form
Liquid
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery times may vary depending on your location and chosen shipping method. For specific delivery time estimates, please consult your local distributor.
Synonyms
DKFZp781D015 antibody; KIAA0080 antibody; MGC10881 antibody; MGC17226 antibody; Synaptotagmin 11 antibody; Synaptotagmin 12 antibody; Synaptotagmin XI antibody; Synaptotagmin-11 antibody; Synaptotagmin11 antibody; Synaptotagmin12 antibody; SynaptotagminXI antibody; SYT 11 antibody; SYT 12 antibody; Syt XI antibody; Syt11 antibody; SYT11_HUMAN antibody; SYT12 antibody; SytXI antibody
Target Names
SYT11
Uniprot No.
Target Background
Function
Synaptotagmin 11 (SYT11) is a member of the synaptotagmin family involved in vesicular and membrane trafficking. Unlike other family members, SYT11 does not bind calcium (Ca2+). It functions as an inhibitor of clathrin-mediated and bulk endocytosis, ensuring precise vesicle retrieval. SYT11 plays a crucial role in dopamine transmission by regulating endocytosis and the vesicle recycling process. It is an essential component of a neuronal vesicular trafficking pathway distinct from the synaptic vesicle trafficking pathway, but crucial for development and synaptic plasticity. In macrophages and microglia, SYT11 inhibits conventional cytokine secretion (at least IL6 and TNF) and phagocytosis. Within astrocytes, it regulates lysosome exocytosis, a mechanism vital for repairing damaged astrocyte cell membranes. Finally, SYT11 is required for ATP13A2-mediated regulation of the autophagy-lysosome pathway.
Gene References Into Functions
- ATP13A2 and SYT11 form a functional network in the regulation of the autophagy-lysosome pathway, which may contribute to Parkinson's Disease-associated neurodegeneration. PMID: 27278822
- Parkin deficiency induces synaptotagmin-11 accumulation and PD-like neurotoxicity in mouse models. This neurotoxicity is reversed by SYT11 knockdown in the substantia nigra pars compacta (SNpc) or knockout of SYT11 restricted to dopaminergic neurons. PMID: 29311685
- Research suggests an association between Parkinson disease and markers in or around SYT11. PMID: 26944171
- Genetic variations in VAMP2 and Synaptotagmin XI may indicate a relationship between these genes and idiopathic generalized epilepsy. PMID: 24164654
- Parkin interacts with and ubiquitinates synaptotagmin XI. PMID: 12925569
- A detailed analysis of a large sample of familial and sporadic Parkinson's disease patients revealed no disease-causing mutations in the synaptotagmin XI gene, arguing against a major role for mutations in this gene in PD. PMID: 15354386
- Excessive expression of SYT11 may be associated with schizophrenia. PMID: 17192956
Database Links
Protein Families
Synaptotagmin family
Subcellular Location
Cytoplasmic vesicle membrane; Single-pass membrane protein. Perikaryon. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Recycling endosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass membrane protein. Perikaryon.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
