Function
TAF14B is a negative regulator of flowering, controlling H4K5 acetylation levels within the FLC and FT chromatin. It positively regulates FLC expression. Furthermore, TAF14B is a component of the transcription factor IID (TFIID) complex, essential for mediating RNA polymerase transcription regulation. It is also a component of the SWR1 complex, mediating the ATP-dependent exchange of histone H2A for the H2A variant HZT1, thereby regulating gene transcription through chromatin remodeling. Finally, TAF14B is part of the NuA4 histone acetyltransferase complex, involved in transcriptional activation of specific genes, primarily through acetylation of nucleosomal histones H4 and H2A.