TAB1 Monoclonal Antibody
Description
Applications of TAB1 Monoclonal Antibodies in Research
TAB1 monoclonal antibodies are widely used for:
Key Studies:
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TAK1 Activation: TAB1 binding induces TAK1 autophosphorylation, activating downstream JNK and NF-κB pathways critical in inflammation and cancer .
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p38α MAPK Interaction: TAB1 directly activates p38α, contributing to stress responses and apoptosis .
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Infectious Disease Role: TAB1-linked pathways influence cytokine storms in severe viral infections (e.g., COVID-19) .
Therapeutic Implications:
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Cancer: TAB1 overexpression correlates with tumor progression in breast and pancreatic cancers .
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Autoimmune Diseases: Inhibiting TAB1-TAK1 interaction reduces inflammation in rheumatoid arthritis models .
Challenges and Considerations
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Species Cross-Reactivity: Some clones (e.g., C25E9) show limited reactivity to non-human primates .
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Batch Variability: Protein A-purified antibodies may require revalidation for quantitative assays .
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Off-Target Effects: TAB1 antibodies may cross-react with homologous proteins in low-stringency conditions .
