ADA2B Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ADA2B antibody; PRZ1 antibody; At4g16420 antibody; dl4235c antibody; Transcriptional adapter ADA2b antibody; AtADA2b antibody; Protein PROPORZ 1 antibody
Target Names
ADA2B
Uniprot No.
Target Background
Function
ADA2B is a crucial component in transcriptional regulation, particularly for acidic activation domains. These domains activate transcription from distant sites, and while the exact mechanism of ADA2B's involvement is not fully understood, it plays a significant role. ADA2B enhances the acetyltransferase activity of GCN5, an enzyme that modifies histones. This enhancement likely occurs by promoting the accessibility of promoter regions for GCN5. Furthermore, ADA2B mediates signaling pathways influenced by auxin and cytokinin, hormones involved in cell proliferation. It is also implicated in the repression of a freezing tolerance pathway under warm temperatures. Notably, ADA2B contributes to the positive regulation of gene expression in response to salt stress by maintaining specific acetylation patterns on histones H4 and H3.
Gene References Into Functions
- In collaboration with GCN5, ADA2B is essential for coupling nuclear content with cell growth and morphogenesis in leaves and trichomes. PMID: 29846775
- ADA2b is required for the expression of genes involved in abiotic stress responses by controlling H3 and H4 acetylation. PMID: 21897124
- The role of SGF29a and ADA2b in salt stress responses was explored, highlighting their importance in this process. PMID: 21193996
- PRZ1, a related protein, participates in the modulation of histone modifications and associated adjustments in gene expression of KIP RELATED PROTEIN (KRP) CDK inhibitor genes in response to auxin. PMID: 20479223
Database Links
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in roots, leaves, stems, flowers and siliques, with the strongest activity in the meristematic zones.
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