TAL1 Antibody, FITC conjugated

1. HOPX is functionally regulated by SCL during hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
2. NF-E2, TAL1, and KLF1, all activators, play a primary role in HSs formation within the LCR. PMID: 27026582
3. Mutations of SF3B1 can block erythropoiesis through dysregulation of alternative RNA splicing of the transcription factor TAL1. PMID: 28545085
4. FOXP3 functions as a tumor suppressor in T-ALL by modulating TAL1 transcriptional activity. PMID: 26686090
5. This review highlights recent findings that elucidate the intricacies of TAL1 (epi)genetic regulation and the transcription network orchestrated by this major T-cell oncogene. PMID: 27443261
6. Deletions of TAL1 are associated with acute T-lymphoblastic leukemia. PMID: 27759908
7. SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in both normal and malignant hematopoiesis. PMID: 28179281
8. Upregulation of TAL1 is associated with T-cell acute lymphoblastic leukemia. PMID: 26882564
9. Concurrent exogenous expression of three transcription factors, GATA1, FLI1, and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells. PMID: 27052461
10. This analysis focuses on a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter. PMID: 25971621
11. Successful induction of gamma-globin expression involves a reduction in BCL11A, KLF1, and TAL1 expression. PMID: 26053062
12. SCL-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. PMID: 25292191
13. These results indicate that KLF1 plays a role in facilitating and/or stabilizing GATA-1 and TAL1 occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping. PMID: 25528728
14. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. PMID: 25564442
15. SCL/TAL1 is located in the upstream of the MEK/ERK pathway and partially regulates hematopoiesis by modulating the phosphorylation level of key proteins within the MEK/ERK pathway. PMID: 24405580
16. This study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene; MYB binds to this new site. PMID: 25394790
17. The results indicate that TAL1 plays a crucial role in chromatin loop formation between the gamma-globin genes and the locus control region, which is a critical step for the transcription of the gamma-globin genes. PMID: 24470145
18. The SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome, which could allow for individual therapeutic stratification for T-ALL patients. PMID: 24040098
19. This study reveals a novel molecular mechanism involving changes in three-dimensional chromatin interactions that activate the TAL1 oncogene in human T-cell leukemia. PMID: 23698277
20. TAL1 is involved in regulating H3K27me3 variations in collaboration with GFI1B. PMID: 24395799
21. There is an occurrence of TAL1 and MYC translocations in early thymocyte ontogeny, but subsequent oncogenic alterations were required to drive oncogenesis in T-cell acute lymphoblastic leukemia. PMID: 24249258
22. These findings redefine how TAL1 and neighboring genes communicate within the nucleus, and indicate that looping facilitates both normal and aberrant TAL1 expression and may predispose to structural rearrangements in T-cell acute lymphoblastic leukemia. PMID: 24200685
23. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. PMID: 23857984
24. We validate a small set of TAL1-regulated microRNA genes whose role is important in T-cell acute lymphoblastic leukemia. PMID: 23448994
25. Transcriptional regulators cooperate to establish or maintain primitive stem cell-like signatures in leukemic cells. PMID: 23327922
26. Consistent with the dual roles of TAL1 in transcription, TAL1-associated LSD1 is decreased while recruitment of hSET1 is increased at the TAL1 targets during erythroid differentiation. PMID: 22310283
27. TAL1 binds to the EPO-R promoter to activate EPO-R expression. PMID: 22982397
28. A novel role for GATA-4 and TAL1 is demonstrated in affecting skeletal myogenic differentiation and EPO response via cross-talk with Sirt1. PMID: 22773876
29. TAL1 forms a positive interconnected autoregulatory loop with GATA3 and RUNX1, and the TAL1 complex directly activates the MYB oncogene. PMID: 22897851
30. The association between single nucleotide polymorphisms (SNPs) of the TAL1 gene, one of the candidate genes of leukemia and schizophrenia, is reported. PMID: 21407147
31. SCL was the 11th most upregulated transcript during the first 4 days of the human embryonic stem cells differentiation process. PMID: 21937587
32. Results indicate that the HDACi-mediated apoptotic program in T-ALL cells is partially dependent on their capacity to downregulate TAL1 and provide support for the therapeutic use of HDACi in T-ALL. PMID: 21647153
33. The genome-wide binding sites for the SCL in primary human megakaryocytes to identify the essential regulator of complex mammalian differentiation processes. PMID: 21571218
34. TAL1 interacts with RUNX1 and ETS1, and these transcription factors are critically required for TAL1 binding to genes that modulate T-cell differentiation. PMID: 21179004
35. In human TAL1-expressing T-ALL cell lines, TAL1 directly activates NKX3.1. PMID: 20855495
36. This data opens up several areas for further investigation and adds new layers of complexity to our understanding of the regulation of SCL expression. PMID: 20140202
37. TAL-1, a basic-helix-loop-helix transcription factor, plays a key role in the formation and functioning of both blood and endothelial systems. (Review) PMID: 19527627
38. Tal1 expression activated UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity. PMID: 20028976
39. High-level hematopoietic chimeras were generated using donor cells from mice transgenic for the stem cell leukaemia 3' enhancer human placental alkaline phosphatase reporter construct to demonstrate vascular contribution potential of fetal liver cells. PMID: 19785037
40. This study examines the role of hypoxia in stimulating phosphorylation, ubiquitination, and proteasomal breakdown in endothelial cells. PMID: 11904294
41. The SCL locus can rescue knockout scl(-/-) mice. PMID: 12010791
42. Ectopic expression of human TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation, but did not cause leukemia. PMID: 12091340
43. TAL1 regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. PMID: 12239153
44. TAL1 is a survival factor for erythroid cells. PMID: 12867998
45. These results indicate that TAL1 can affect both T cell proliferation and differentiation. PMID: 14651981
46. Enforced expression of a TAL1 protein deleted of its DNA-binding domain mimicked most TAL1 effects except for the LTC-IC enhancement, the down-regulation of the CD34 surface marker, and the GPA(+) cell production. PMID: 14715640
47. TAL-1 modulates the angiogenic response of endothelial cells by stimulating cell morphogenesis and influencing their migration behavior. PMID: 14970264
48. A possible role for SCL in renal vasculogenesis is suggested. Undifferentiated mesenchymal cells expressing SCL during early nephrogenesis might represent putative progenitors that can simultaneously give rise to kidney, blood, and endothelium. PMID: 15086455
49. Tal1/SCL binding to pericentromeric DNA represses transcription. PMID: 15677454
50. Results show striking coexpression of SCL and its immediate downstream neighbor, MAP17, suggesting they share regulatory elements. PMID: 15923636

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HGNC: 11556

OMIM: 187040

KEGG: hsa:6886

STRING: 9606.ENSP00000294339

UniGene: Hs.705618