ccdc59 Antibody
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In Stock 
Description
Validated Applications
The antibody is optimized for:
| Application | Recommended Dilution | Validation |
|---|---|---|
| Western Blot (WB) | 1:1000–1:4000 | Detected in MCF-7 cells |
| Immunoprecipitation (IP) | 0.5–4.0 µg per 1.0–3.0 mg lysate | Tested in HepG2 cells |
| Immunohistochemistry (IHC) | 1:50–1:500 | Human lung cancer tissue (antigen retrieval with TE buffer pH 9.0 or citrate buffer pH 6.0) |
| ELISA | N/A (protocol available) | N/A |
Note: Titration is recommended for optimal results .
Tissue Expression and Subcellular Localization
CCDC59 exhibits nucleolar and cytoplasmic expression across diverse tissues, including:
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Brain: Cerebellum, cerebral cortex, hippocampus.
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Blood: Leukocytes.
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Cancer: Overexpression in breast, lung, and pancreatic cancer .
Subcellular Distribution:
Role in Pulmonary Surfactant Regulation
CCDC59 interacts with transcription factors (e.g., Nkx-2.1) to enhance surfactant protein B (SFTPB) and C (SFTPC) promoter activities, critical for lung function .
Cancer Implications
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Elevated CCDC59 expression is observed in malignancies, suggesting roles in oncogenesis or tumor progression .
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Antibody-based targeting may offer diagnostic or therapeutic potential, though mechanisms remain under investigation .
Protocols and Resources
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Composition: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Composition: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ccdc59 antibody; si:dkey-21h14.2 antibody; Thyroid transcription factor 1-associated protein 26 homolog antibody
Target Names
ccdc59
Uniprot No.
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