TAS1R2 Antibody, Biotin conjugated

1. Genetic association studies conducted on a population of preschool-aged children in Guelph, Ontario, revealed that single nucleotide polymorphisms (SNPs) in CD36 (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (rs713598) were associated with snacking behavior in the studied population. [PILOT PROJECTS] PMID: 29385734
2. Our research indicates that the binding of agonists to the VFD2 region of TAS1R2 triggers significant conformational changes, resulting in the formation of a TM6/TM6 interface between the transmembrane domains of TAS1R2 and TAS1R3. This observation aligns with the activation process observed biophysically on the metabotropic glutamate receptor 2 homodimer. PMID: 28228527
3. Alleles from each TAS1R2 locus (GG compared to AA alleles of rs12033832, and CT/CC compared to TT alleles of rs35874116) were associated with higher consumption of carbohydrates (as a percentage of total energy intake) and higher amounts of sweet foods, respectively (P<0.05). PMID: 29110749
4. A detailed molecular structure of the sweet taste receptor dimers T1R2-T1R3 has been presented. PMID: 27936499
5. While no significant associations were observed between GLUT2 and/or TAS1R2 polymorphisms and tooth fillings, allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. Additionally, no significant interaction between these two genes and the risk of dental caries was found. These findings suggest that GLUT2 and TAS1R polymorphisms might influence the risk of caries in the Czech population. PMID: 26112465
6. In conclusion, the Val/Val genotype of TAS1R2 was associated with higher carbohydrate intake and hypertriglyceridemia (HTG). PMID: 26907331
7. A high-risk caries experience (>8 caries) was found to be associated with the TAS1R2 rs35874116 homozygous polymorphic genotype. PMID: 25924601
8. The rs12033832 single nucleotide polymorphism in TAS1R2 is associated with sucrose taste and sugar intake; however, the effect varies depending on the individual's body mass index (BMI). PMID: 26279452
9. Studies have elucidated the human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3. PMID: 25029362
10. Research suggests that the effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3. PMID: 24068707
11. Interaction studies between brazzein and the amino terminal domain of the sweet receptor subunit T1R2 demonstrated a stronger interaction at 7 degrees Celsius than at 37 degrees Celsius. This low temperature conformation, which alters the orientations of two loops known to be critical for the sweetness of brazzein, might represent the bound state of brazzein in the complex with the human sweet receptor. PMID: 23349025
12. TAS1R2 has been linked to caries risk. PMID: 23257979
13. Genetic ablation of the sweet TR protein T1R2 completely eliminates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion both in vitro and in vivo. PMID: 22315413
14. The sweet taste receptor T1R2/T1R3 plays a role in glucose-dependent secretion of satiation peptides. PMID: 21540445
15. Our research findings demonstrate that a genetic variation in TAS1R2 affects habitual sugar consumption and may contribute to interindividual differences in behavioral changes in response to dietary counseling. PMID: 20943793
16. Significant associations have been observed in TAS1R2 for caries risk and/or protection. PMID: 20858777
17. Data suggests that positive allosteric modulators of the sweet taste receptor could contribute to reducing the caloric content in food and beverages while maintaining the desired taste. PMID: 20173092
18. Results obtained from mutagenesis and chimera studies of the receptor indicate that brazzein interacts with both T1R2 and T1R3, and that the Venus flytrap module of T1R2 is crucial for brazzein agonism. PMID: 20302879
19. Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners have been detected using saturation transfer difference NMR spectroscopy. PMID: 19664591
20. The mechanism of interaction between the sweet protein monellin and the T1R2-T1R3 receptor has been investigated. PMID: 12706725
21. It has been established that sweet and umami taste are strictly dependent on T1R-receptors, and studies have shown that the selective elimination of T1R-subunits differentially abolishes the detection and perception of these two taste modalities. PMID: 14636554
22. Water rinses remove inhibitors from the heteromeric sweetener receptor TAS1R2-TAS1R3, leading to cell activation and the perception of strong sweetness from pure water. PMID: 16633339
23. Some of the amino acid positions critical for the activation of hTAS1R2+hTAS1R3 by neohesperidin dihydrochalcone are involved in the binding of allosteric modulators in other class C GPCRs. PMID: 17935609

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HGNC: 14905

OMIM: 606226

KEGG: hsa:80834

STRING: 9606.ENSP00000364520

UniGene: Hs.553548