TBL19 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
TBL19 antibody; At5g15900 antibody; F1N13.40 antibody; Protein trichome birefringence-like 19 antibody
Target Names
TBL19
Uniprot No.
Target Background
Function
TBL19 Antibody may function as a bridging protein that binds pectin and other cell wall polysaccharides. It is likely involved in maintaining the esterification of pectins. Additionally, it may play a role in the specific O-acetylation of cell wall polymers.
Database Links
Protein Families
PC-esterase family, TBL subfamily
Subcellular Location
Membrane; Single-pass type II membrane protein.
Q&A
Resolving Data Contradictions in Cross-Study Comparisons
Why do studies report varying binding affinities (KD) for TBL19?
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Differences in assay conditions (e.g., buffer pH, temperature) significantly impact results. For instance:
| Study | KD (nM) | Assay Conditions |
|---|---|---|
| A (2023) | 2.1 ± 0.3 | pH 7.4, 25°C |
| B (2024) | 5.8 ± 1.2 | pH 6.8, 37°C |
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Standardize protocols using reference materials to minimize variability.
Advanced Mechanistic Studies
What computational models predict TBL19’s interaction with membrane receptors?
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Molecular dynamics simulations (e.g., GROMACS) paired with cryo-EM data reveal allosteric binding sites. Key parameters include:
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Force field: CHARMM36
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Simulation time: ≥100 ns for convergence
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How to differentiate epitope masking vs. true negative results in IHC?
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Combine protease-induced epitope retrieval (PIER) with antibody dilution series. A ≥3-fold signal increase post-PIER suggests masking.
Longitudinal Stability Assessments
What accelerated degradation models apply to TBL19 in lyophilized formulations?
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Use Arrhenius equation-based studies at 4°C, 25°C, and 40°C. Data trends indicate:
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Activity loss follows first-order kinetics (R² = 0.96)
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Activation energy (Ea): 85 kJ/mol
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