TBX18 Antibody
Description
Introduction
The TBX18 antibody is a targeted immunoglobulin designed to detect the T-box transcription factor 18 (TBX18), a critical regulator of embryonic development and tissue differentiation. TBX18 is expressed in mesenchymal cells during organogenesis, influencing structures such as the heart, ureter, and prostate . The antibody facilitates research into TBX18’s role in developmental biology, disease modeling, and regenerative medicine.
Applications of TBX18 Antibody
Role in Tissue Development
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Prostatic Stromal Differentiation: TBX18 is essential for smooth muscle cell (SMC) maturation in the prostate stroma. Its absence leads to myofibroblast hypertrophy and epithelial disorganization .
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Cardiac Pacemaker Function: Overexpression of TBX18 in cardiomyocytes induces pacemaker-like electrical activity, suggesting therapeutic potential for heart block treatment .
Disease Implications
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Prostate Pathology: Dysregulated TBX18 correlates with stromal-epithelial signaling defects, potentially linked to benign prostatic hyperplasia (BPH) and cancer .
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Heart Block Models: TBX18 mRNA delivery restores pacing in porcine models of complete heart block, highlighting its regenerative capacity .
Product Specs
Target Background
- Tbx18-positive cells constitute a portion of the progenitor endothelial (PE) cells in the initial phase of differentiation and subsequently include smooth muscle cells (SMCs) as well as fibroblasts. These findings suggest that Tbx18-positive cells serve as a PE progenitor, supplying a variety of cells that contribute to the formation of coronary arteries. PMID: 28794400
- Gene product expressions of SHH, TBX18, and TSHZ3 are statistically higher in patients with ureteropelvic junction (UPJ) obstruction compared to the control group. This suggests a reactivation of the processes that were active during the embryonic period, possibly due to chronic inflammation and long-term micro-trauma caused by the disease. PMID: 27381532
- Data indicate that the human T-box 18 (TBX18) gene induces rat adipose-derived stem cells (ADSCs) to differentiate into pacemaker-like cells in the cardiac microenvironment. PMID: 27632938
- Mutations in TBX18 cause dominant urinary tract malformations through transcriptional dysregulation of ureter development. PMID: 26235987
- The DNA sequence variants within the TBX18 gene promoter identified in ventricular septal defects (VSD) patients may be implicated in the etiology of VSD. PMID: 23749171
- Connexin43 transcriptional suppression by TBX18 undermines cardiomyocyte cell-cell electrical coupling. PMID: 21205823
- Tbx18 interacts with Gata4 and Nkx2-5 and competes with Tbx5-mediated activation of the cardiac natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo. PMID: 17584735
