tbx-2 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
tbx-2 antibody; F21H11.3 antibody; T-box protein 2 antibody
Target Names
tbx-2
Uniprot No.
Target Background
Function
TBX-2, a transcription factor in Caenorhabditis elegans, plays a crucial role in the regulation of genes involved in the development of pharyngeal muscles derived from the ABa lineage. It acts as a transcriptional repressor, binding to T-box binding sites within its own promoter to negatively autoregulate its expression in neurons, seam cells, and the gut. This self-regulation ensures the precise restriction of TBX-2 expression to specific tissues. Notably, TBX-2 may cooperate with the NF-Y complex (NFYA-1) to further repress its own expression.
Gene References Into Functions
- Reduced SUMOylation significantly amplifies the effects of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development. This suggests that the repression of downstream targets of TBX-2 relies on SUMOylation. PMID: 23595631
- Ce-TBX-2, the homologue of the TBX2/TBX3 transcriptional factor in Caenorhabditis elegans, is directly involved in olfactory adaptation. PMID: 14750151
- TBX-2 and SUMO-conjugating enzymes are indispensable for the development of ABa-derived pharyngeal muscle, suggesting that TBX-2 function is dependent on sumoylation. PMID: 16701625
- Evidence suggests that a positive feedback loop between tbx-2 and pha-4 is essential for blastomere-derived precursors to commit to pharyngeal muscle fate. PMID: 17005176
- In screens for mutants with abnormal HSN motor neuron development, TBX-2, the T-box protein, was identified as a crucial factor for both HSN and PHB sensory neuron differentiation. PMID: 18505863
Database Links
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in body wall muscles and a subset of pharyngeal neurons. Expressed in head neurons and occassionally tail neurons. Not expressed in the pharynx.
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