TCF7L2 Antibody

1. This study investigated the association between single nucleotide polymorphisms in the Transcription factor 7-like 2 (TCF7L2) gene and genetic predisposition to type 2 diabetes in nonobese patients. PMID: 28263491
2. A meta-analysis indicated a significant association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus across various ethnicities, including Caucasians, East Asians, South Asians, and others. [Meta-analysis] PMID: 29514658
3. The study revealed an interaction between the responses of insulin and HOMA-IR to ALE supplementation and single-nucleotide polymorphism rs7903146 in TCF7L2. PMID: 30177026
4. This research highlighted the significance of the two variants of the TCF7L2 gene as crucial genetic risk factors for the development of type 2 diabetes in the Han ethnic group of China. PMID: 30266127
5. The study demonstrated that carriers of the homozygous TT allele exhibited altered postprandial triglyceride response, primarily affecting very low density lipoproteins and high-density lipoproteins subclasses. This suggests a genotype-mediated effect on hepatic lipid regulation. PMID: 28220878
6. The study indicated a significant connection between DEFB1 and TCF7L2 gene polymorphisms and nephrolithiasis. PMID: 29959006
7. Stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose conditions. However, it also reduced MEK/MAPK phosphorylation, decreased anchorage-independent growth, and modulated the expression of GLUT1 and Ras pathway-related proteins. PMID: 29301589
8. The study showed an association between TCF7L2 SNPs (rs7903146, rs12255372, and rs10885406) and a high total cholesterol/high-density lipoproteins ratio. These findings emphasize the influence of TCF7L2 SNPs on altered lipid profiles in the Balinese population, which may further link to the risk of cardiovascular diseases. PMID: 30027476
9. This research suggests that the TCF7L2 rs7903146 polymorphism might be associated with susceptibility to diabetic nephropathy in the Chinese Han population, while rs290487 might not. The strong linkage disequilibrium observed between the two single nucleotide polymorphisms, particularly the T-T haplotype (rs7903146-rs290487), increased the susceptibility to diabetic nephropathy. PMID: 30290587
10. The study determined that the T risk allele of the rs7903146 in the TCF7L2 gene elevates the risk of type 2 diabetes. PMID: 29631902
11. Common variation at TCF7L2 was found to influence acute responses to both glipizide and metformin in individuals without diabetes. This highlights altered incretin signaling as a potential mechanism by which TCF7L2 variation increases the risk of type 2 diabetes. PMID: 29326107
12. No correlation was observed between the studied polymorphisms of the TCF7L2 gene and gestational diabetes mellitus (GDM). PMID: 27958632
13. Type 1 diabetes mellitus patients carrying the TCF7L2 variant exhibited a milder immunologic and metabolic phenotype at type 1 diabetes diagnosis, potentially driven by type 2 diabetes-like pathogenic mechanisms. PMID: 29025879
14. The SNPs in TCF7L2 and HHEX were genotyped using polymerase chain reaction-restriction fragment length polymorphism. No significant differences were found in the distribution of genotypes and alleles between polycystic ovary syndrome cases and controls. PMID: 26563606
15. rs122555372 was associated with pancreatic reserve in patients with type 2 diabetes, and with fasting glucose and beta-cell function in individuals without diabetes. PMID: 28101933
16. TCF7L2 mRNA expression is downregulated in individuals with impaired glucose tolerance and adipocyte insulin resistance. PMID: 29317436
17. PGC-1alpha induction during differentiation is essential for both mitochondrial biogenesis and commitment to the hepatocytic lineage. TCF7L2 repression is sufficient to increase PGC-1alpha expression, mitochondrial biogenesis, and OXPHOS activity. PMID: 28795454
18. TCF7L2 plays a role in dermal papilla cell proliferation. PMID: 24354472
19. Silencing the tcf4 gene confers sensitivity to oxaliplatin in colorectal cancer cells. PMID: 24869759
20. GRbeta bound to the N-terminus domain of TCF-4. Its influence on Wnt signaling required both ligand- and DNA-binding domains. This is sufficient to maintain the TCF/LEF activity at a high level in the absence of beta-catenin stabilization. PMID: 25301232
21. TRIB2 negatively regulates Wnt activity through a reduction in protein stability of TCF4 and beta-Catenin. PMID: 25311538
22. CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. These findings indicate a novel role of CtBPs in the promotion of CSC growth and self-renewal. PMID: 25483087
23. The study revealed that low TCF4 protein expression was a useful predictive factor for favorable tumor response to nCRT and better outcomes in patients with LARC. PMID: 25519018
24. These results suggest that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
25. KLF5 facilitates lysophosphatidic acid-induced interaction between beta-catenin and TCF4. PMID: 25683913
26. The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated beta-catenin by sequestering TCF4 to the nuclear membrane. PMID: 26350900
27. This research provides evidence that TCF4 and ZEB1 modulate each other's transcriptional activity in the regulation of tumor pro-invasive Wnt target genes. PMID: 26387539
28. The expression of NLK was negatively correlated with TCF4 expression in lung cancers. PMID: 26823848
29. The data indicated that the beta-catenin/Tcf4 interaction is disrupted by BC-23. PMID: 27014877
30. This research demonstrated that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. PMID: 27129219
31. These findings suggest a potential linkage between prostate cancer (PCa) chemoresistance and exosome regulatory networks. This study proposes that AR, PTEN, and TCF4 genes may be important targets regulated by exosome miRNAs in chemoresistant cancer cells. PMID: 27278879
32. G-17 caused the overexpression of beta-catenin and TCF-4. PMID: 27430592
33. Collectively, these results suggest that the newly identified Rock2-beta-catenin/TCF4-SCARA5 axis provides valuable insights into the regulatory mechanisms of proliferation in human renal cell carcinoma (RCC). PMID: 27793664
34. This study identified Dickkopf-related protein 3 (DKK3) as a direct target of miR-25 in vitro. Upregulation of DKK3 partially attenuated the oncogenic effect of miR-25 on melanoma cells. Ectopic expression of miR-25 in melanoma cells induced beta-catenin accumulation in the nucleus and inhibited TCF4 (T cell factor 4) activity, as well as the expression of c-Myc and Cyclin D1. PMID: 27801786
35. FOXN3 binds to beta-catenin and inhibits beta-catenin/TCF signaling by blocking the interaction between beta-catenin and TCF4. Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. PMID: 28039460
36. High TCF4 expression is associated with colorectal cancer. PMID: 28921929
37. Overexpression of vPK led to reduced mRNA expression of cyclin D1, a well-known transcriptional product of Wnt signaling. This suggests that vPK effectively regulates the host signaling pathway through direct interactions with cellular proteins. PMID: 29432739
38. TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with gestational diabetes mellitus (GDM). PMID: 27465520
39. The TCF7L2 rs7903146 polymorphism is associated with ischemic heart disease. PMID: 28299838
40. The IVS3C>T locus in the TCF7L2 gene was not found to be independently statistically significantly associated with the development of type 2 Diabetes Mellitus in the Kyrgyz population. PMID: 29171469
41. A meta-analysis revealed that six out of eight SNPs showed significant associations between TCF7L2 variants and gestational diabetes mellitus (GDM) risk in the overall population. The most influential SNPs were rs7903146, rs12255372, and rs7901695. However, the contribution of these SNPs to GDM risk varied across different racial/ethnic groups. PMID: 28002648
42. The study found that rs12573128 is significantly associated with an increased risk of schizophrenia (SCZ) in the Chinese Han population. PMID: 28404897
43. The study suggested that TCF7L2 SNPs (rs1225404 and rs7003146) might be associated with breast cancer risk in Northwest Chinese Han populations. PMID: 27738320
44. These findings further support the hypothesis that TCF7L2 gene variation contributes to diabetogenesis in a subset of young individuals with type 1 diabetes. PMID: 27027642
45. The rs7903146 variant in the TCF7L2 gene increases the risk of impaired glucose tolerance or type 2 diabetes in obese adolescents by impairing beta-cell function. Hepatic insulin sensitivity predicts the development of impaired glucose tolerance or type 2 diabetes over time. PMID: 28611053
46. In conclusion, TCF7L2 regulates estradiol- or progesterone-modulated islet and hepatic glucose metabolism. PMID: 27108846
47. A meta-analysis found that TCF7L2 rs7903146 and the 112/112 haplotype of CAPN10 might be associated with gestational diabetes risks. PMID: 28277135
48. The study observed that KIF23 was regulated by TCF-4 at the transcriptional level. This evidence indicates that KIF23 overexpression is associated with glioma malignancy and a worse survival time in glioma. PMID: 27013586
49. These findings suggest that the association between TCF7L2 SNP rs12255372 and HDL-C may be modified by dietary fat intake in the Asian Indian population. PMID: 29182660
50. The Wnt Signaling Pathway Effector TCF7L2 plays a role in glucose homeostasis. PMID: 27159876

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HGNC: 11641

OMIM: 125853

KEGG: hsa:6934

STRING: 9606.ENSP00000444972

UniGene: Hs.593995